You need JavaScript to view this

A BanI RFLP at a deletion hotspot in the human dystrophin gene

Abstract

Cf56a is a 0.9 kb EcoRI fragment of dystrophin cDNA in pUC13. Cf56a is identical to Kunkel's cDNA probe 8. Constant bands of 14.4, 11.0, 8.1, 6.2 and 1.3 kb correspond to exons I, N, L, N and K respectively. The polymorphic band is exon J (exon 48, 1.2+3.9 kb HindIII bands). This exon is deleted in 25% of all Duchenne/Becker dystrophy boys. Therefore this RFLP is useful for determining carrier status of at-risk females by showing heterozygosity or apparent non-maternity.
Authors:
Read, A P; Mountford, R [1] 
  1. St. Mary's Hospital, Manchester (England)
Publication Date:
Jan 25, 1990
Product Type:
Journal Article
Reference Number:
EDB-90-159232
Resource Relation:
Journal Name: Nucleic Acids Research; (UK); Journal Volume: 18:2
Subject:
59 BASIC BIOLOGICAL SCIENCES; RECOMBINANT DNA; DNA SEQUENCING; RFLPS; DNA HYBRIDIZATION; GENES; GENETIC MAPPING; HUMAN POPULATIONS; HUMAN X CHROMOSOME; PLASMIDS; CELL CONSTITUENTS; CHROMOSOMES; DNA; HETEROCHROMOSOMES; HYBRIDIZATION; MAPPING; NUCLEIC ACIDS; ORGANIC COMPOUNDS; POPULATIONS; STRUCTURAL CHEMICAL ANALYSIS; X CHROMOSOME; 550200* - Biochemistry
OSTI ID:
6534782
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0305-1048; CODEN: NARHA
Submitting Site:
JMT
Size:
Pages: 385
Announcement Date:

Citation Formats

Read, A P, and Mountford, R. A BanI RFLP at a deletion hotspot in the human dystrophin gene. United Kingdom: N. p., 1990. Web. doi:10.1093/nar/18.2.385.
Read, A P, & Mountford, R. A BanI RFLP at a deletion hotspot in the human dystrophin gene. United Kingdom. doi:10.1093/nar/18.2.385.
Read, A P, and Mountford, R. 1990. "A BanI RFLP at a deletion hotspot in the human dystrophin gene." United Kingdom. doi:10.1093/nar/18.2.385. https://www.osti.gov/servlets/purl/10.1093/nar/18.2.385.
@misc{etde_6534782,
title = {A BanI RFLP at a deletion hotspot in the human dystrophin gene}
author = {Read, A P, and Mountford, R}
abstractNote = {Cf56a is a 0.9 kb EcoRI fragment of dystrophin cDNA in pUC13. Cf56a is identical to Kunkel's cDNA probe 8. Constant bands of 14.4, 11.0, 8.1, 6.2 and 1.3 kb correspond to exons I, N, L, N and K respectively. The polymorphic band is exon J (exon 48, 1.2+3.9 kb HindIII bands). This exon is deleted in 25% of all Duchenne/Becker dystrophy boys. Therefore this RFLP is useful for determining carrier status of at-risk females by showing heterozygosity or apparent non-maternity.}
doi = {10.1093/nar/18.2.385}
journal = {Nucleic Acids Research; (UK)}
volume = {18:2}
journal type = {AC}
place = {United Kingdom}
year = {1990}
month = {Jan}
}