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Antigens of hepatitis B virus: failure to detect HBeAg on the surfaces of HBsAg forms

Abstract

The particulate forms of HBsAg were analysed for the presence of HBeAG on their surfaces. By immunodiffusion analysis, anti-HBe did not form precipitin bands with the purified forms of HBsAg and hyperimmune guinea pig antisera to these forms did not react with HBeAg. Lines of non-identity were observed between the HBeAg determinants (e/sub 1/ and e/sub 2/) and the Dane particles and filaments isolated from an HBeAg-positive serum. Finally, anti-HBe failed to precipitate the polymerase-positive subpopulation of Dane particles, indicating that anti-HBe has no direct role in virus neutralization.
Authors:
Gerin, J L; [1]  Shih, J W.K.; McAuliffee, V J; Purcell, R H
  1. Oak Ridge National Lab., Rockville, MD
Publication Date:
Jan 01, 1978
Product Type:
Journal Article
Reference Number:
ERA-04-028024; EDB-79-044875
Resource Relation:
Journal Name: J. Gen. Virol.; (United Kingdom); Journal Volume: 38
Subject:
59 BASIC BIOLOGICAL SCIENCES; ANTIGENS; IMMUNE REACTIONS; VIRUSES; HEPATITIS; PARTICLES; DIGESTIVE SYSTEM DISEASES; DISEASES; MICROORGANISMS; PARASITES; 550700* - Microbiology
OSTI ID:
6530861
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JGVIA
Submitting Site:
TIC
Size:
Pages: 561-566
Announcement Date:
Mar 01, 1979

Citation Formats

Gerin, J L, Shih, J W.K., McAuliffee, V J, and Purcell, R H. Antigens of hepatitis B virus: failure to detect HBeAg on the surfaces of HBsAg forms. United Kingdom: N. p., 1978. Web.
Gerin, J L, Shih, J W.K., McAuliffee, V J, & Purcell, R H. Antigens of hepatitis B virus: failure to detect HBeAg on the surfaces of HBsAg forms. United Kingdom.
Gerin, J L, Shih, J W.K., McAuliffee, V J, and Purcell, R H. 1978. "Antigens of hepatitis B virus: failure to detect HBeAg on the surfaces of HBsAg forms." United Kingdom.
@misc{etde_6530861,
title = {Antigens of hepatitis B virus: failure to detect HBeAg on the surfaces of HBsAg forms}
author = {Gerin, J L, Shih, J W.K., McAuliffee, V J, and Purcell, R H}
abstractNote = {The particulate forms of HBsAg were analysed for the presence of HBeAG on their surfaces. By immunodiffusion analysis, anti-HBe did not form precipitin bands with the purified forms of HBsAg and hyperimmune guinea pig antisera to these forms did not react with HBeAg. Lines of non-identity were observed between the HBeAg determinants (e/sub 1/ and e/sub 2/) and the Dane particles and filaments isolated from an HBeAg-positive serum. Finally, anti-HBe failed to precipitate the polymerase-positive subpopulation of Dane particles, indicating that anti-HBe has no direct role in virus neutralization.}
journal = []
volume = {38}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Jan}
}