You need JavaScript to view this

Use and limitations of radiolabelled anti-CEA antibodies and their fragments for photoscanning detection of human colorectal carcinomas

Journal Article:

Abstract

Fifty-three patients with histologically proven carcinoma were injected with highly purified (/sup 131/I)-labelled goat antibodies or fragments of antibodies against carcinoembryonic antigen (CEA). Each patient was tested by external photoscanning 4, 24, 36, 48h after injection. In 22 patients (16 of 38 injected with intact antibodies, 5 of 13 with F(ab')/sub 2/ fragments and 1 of 2 with Fab' fragments), an increased concentration of /sup 131/I radioactivity corresponding to the previously known tumor location was detected by photoscanning 36-48 h after injection. Blood pool and secreted radioactivity was determined in all patients by injecting 15 min after scanning, (sup(99m)Tc)-labeled normal serum albumin and free sup(99m)TcO/sub 4//sup -/. The computerized subtraction of sup(99m)Tc from /sup 131/I radioactivity enhanced the definition of tumor localization in the 22 positive patients. However, in spite of the computerized subtraction, interpretation of the scans remained doubtful for 12 patients and was entirely negative for 19 additional patients.
Authors:
Mach, J P; Forni, M; Ritschard, J; Buchegger, F; Carrel, S; Widgren, S; Donath, A; Alberto, P [1] 
  1. Lausanne Univ. (Switzerland)
Publication Date:
Aug 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-12-596144; EDB-81-058909
Resource Relation:
Journal Name: Oncodev. Biol. Med.; (Netherlands); Journal Volume: 1:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIBODIES; BIOLOGICAL LOCALIZATION; CARCINOMAS; RADIOISOTOPE SCANNING; DIAGNOSTIC TECHNIQUES; IODINE 131; LABELLED COMPOUNDS; MAN; SPECIFICITY; TECHNETIUM 99; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DISEASES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; PRIMATES; RADIOISOTOPES; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6530100
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: OBIMD
Submitting Site:
INIS
Size:
Pages: 49-69
Announcement Date:

Journal Article:

Citation Formats

Mach, J P, Forni, M, Ritschard, J, Buchegger, F, Carrel, S, Widgren, S, Donath, A, and Alberto, P. Use and limitations of radiolabelled anti-CEA antibodies and their fragments for photoscanning detection of human colorectal carcinomas. Netherlands: N. p., 1980. Web.
Mach, J P, Forni, M, Ritschard, J, Buchegger, F, Carrel, S, Widgren, S, Donath, A, & Alberto, P. Use and limitations of radiolabelled anti-CEA antibodies and their fragments for photoscanning detection of human colorectal carcinomas. Netherlands.
Mach, J P, Forni, M, Ritschard, J, Buchegger, F, Carrel, S, Widgren, S, Donath, A, and Alberto, P. 1980. "Use and limitations of radiolabelled anti-CEA antibodies and their fragments for photoscanning detection of human colorectal carcinomas." Netherlands.
@misc{etde_6530100,
title = {Use and limitations of radiolabelled anti-CEA antibodies and their fragments for photoscanning detection of human colorectal carcinomas}
author = {Mach, J P, Forni, M, Ritschard, J, Buchegger, F, Carrel, S, Widgren, S, Donath, A, and Alberto, P}
abstractNote = {Fifty-three patients with histologically proven carcinoma were injected with highly purified (/sup 131/I)-labelled goat antibodies or fragments of antibodies against carcinoembryonic antigen (CEA). Each patient was tested by external photoscanning 4, 24, 36, 48h after injection. In 22 patients (16 of 38 injected with intact antibodies, 5 of 13 with F(ab')/sub 2/ fragments and 1 of 2 with Fab' fragments), an increased concentration of /sup 131/I radioactivity corresponding to the previously known tumor location was detected by photoscanning 36-48 h after injection. Blood pool and secreted radioactivity was determined in all patients by injecting 15 min after scanning, (sup(99m)Tc)-labeled normal serum albumin and free sup(99m)TcO/sub 4//sup -/. The computerized subtraction of sup(99m)Tc from /sup 131/I radioactivity enhanced the definition of tumor localization in the 22 positive patients. However, in spite of the computerized subtraction, interpretation of the scans remained doubtful for 12 patients and was entirely negative for 19 additional patients.}
journal = {Oncodev. Biol. Med.; (Netherlands)}
volume = {1:1}
journal type = {AC}
place = {Netherlands}
year = {1980}
month = {Aug}
}