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Changes in rat liver and adipose tissue lipogenesis after single lethal X-irradiation: modification by the restricted food intake

Journal Article:

Abstract

Male rats of Wistar strain were adapted during a 4-week period to the nutritional regimes of meal feeding (MF) and ad libitum (AL) and were irradiated with the single whole-body lethal X-ray dose 14.35 Gy after 22 h of fasting. Within the intervals 1, 24, 48 and 72 h after irradiation lipogenesis changes in the liver were studied by measuring 1-/sup 14/C-acetate incorporation (74 KBq) in the total lipids, fatty acids and cholesterol, and in the white adipose tissue pieces by measuring U-/sup 14/C-glucose incorporation (74 KBq) in the total lipids, fatty acids and glyceride glycerol. Lipogenesis increased in the liver of the irradiated rats as compared with sham irradiated rats and reached the maximal values at 72 h after irradiation in AL animals and at 48 h after irradiation in MF animals. Lipogenesis in the adipose tissue decreased in the irradiated rats as compared with the sham irradiated ones and continued to decrease with the post-irradiation period. The adaptation to the nutritional regime of meal feeding markedly modified lipogenesis in the liver and the adipose tissue of the irradiated rats. Long-term fasting (before and after irradiation) was supposed to be another modifying factor in the lipogenesis changes. Lipogenesis changes  More>>
Authors:
Sedlakova, A; Ahlers, I; Praslicka, M [1] 
  1. Univerzita P.J. Safarika, Kosice (Czechoslovakia). Katedra Vseobecnej Biologie
Publication Date:
Jan 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-14-731727; EDB-83-069911
Resource Relation:
Journal Name: Biologia (Bratislava); (Czechoslovakia); Journal Volume: 36:6
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ADIPOSE TISSUE; BIOLOGICAL RADIATION EFFECTS; LIPIDS; BIOSYNTHESIS; LIVER; RATS; LETHAL IRRADIATION; ACETATES; CARBON 14 COMPOUNDS; CARBOXYLIC ACIDS; CHOLESTEROL; DIET; GLUCOSE; GLYCEROL; LABELLED COMPOUNDS; METABOLISM; RESPONSE MODIFYING FACTORS; TIME DEPENDENCE; TRACER TECHNIQUES; WHOLE-BODY IRRADIATION; X RADIATION; ALCOHOLS; ALDEHYDES; ANIMAL TISSUES; ANIMALS; BIOLOGICAL EFFECTS; BODY; CARBOHYDRATES; CARBOXYLIC ACID SALTS; CONNECTIVE TISSUE; DIGESTIVE SYSTEM; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; GLANDS; HEXOSES; HYDROXY COMPOUNDS; IONIZING RADIATIONS; IRRADIATION; ISOTOPE APPLICATIONS; MAMMALS; MONOSACCHARIDES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SACCHARIDES; STEROIDS; STEROLS; SYNTHESIS; TISSUES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6522726
Country of Origin:
Serbia and Montenegro
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BLOAA
Submitting Site:
HEDB
Size:
Pages: 445-451
Announcement Date:
Mar 01, 1983

Journal Article:

Citation Formats

Sedlakova, A, Ahlers, I, and Praslicka, M. Changes in rat liver and adipose tissue lipogenesis after single lethal X-irradiation: modification by the restricted food intake. Serbia and Montenegro: N. p., 1981. Web.
Sedlakova, A, Ahlers, I, & Praslicka, M. Changes in rat liver and adipose tissue lipogenesis after single lethal X-irradiation: modification by the restricted food intake. Serbia and Montenegro.
Sedlakova, A, Ahlers, I, and Praslicka, M. 1981. "Changes in rat liver and adipose tissue lipogenesis after single lethal X-irradiation: modification by the restricted food intake." Serbia and Montenegro.
@misc{etde_6522726,
title = {Changes in rat liver and adipose tissue lipogenesis after single lethal X-irradiation: modification by the restricted food intake}
author = {Sedlakova, A, Ahlers, I, and Praslicka, M}
abstractNote = {Male rats of Wistar strain were adapted during a 4-week period to the nutritional regimes of meal feeding (MF) and ad libitum (AL) and were irradiated with the single whole-body lethal X-ray dose 14.35 Gy after 22 h of fasting. Within the intervals 1, 24, 48 and 72 h after irradiation lipogenesis changes in the liver were studied by measuring 1-/sup 14/C-acetate incorporation (74 KBq) in the total lipids, fatty acids and cholesterol, and in the white adipose tissue pieces by measuring U-/sup 14/C-glucose incorporation (74 KBq) in the total lipids, fatty acids and glyceride glycerol. Lipogenesis increased in the liver of the irradiated rats as compared with sham irradiated rats and reached the maximal values at 72 h after irradiation in AL animals and at 48 h after irradiation in MF animals. Lipogenesis in the adipose tissue decreased in the irradiated rats as compared with the sham irradiated ones and continued to decrease with the post-irradiation period. The adaptation to the nutritional regime of meal feeding markedly modified lipogenesis in the liver and the adipose tissue of the irradiated rats. Long-term fasting (before and after irradiation) was supposed to be another modifying factor in the lipogenesis changes. Lipogenesis changes in the liver depended on the MF nutritional regime.}
journal = {Biologia (Bratislava); (Czechoslovakia)}
volume = {36:6}
journal type = {AC}
place = {Serbia and Montenegro}
year = {1981}
month = {Jan}
}