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Uptake of /sup 67/Ga in the heart of rats treated with isoproterenol

Journal Article:

Abstract

Gallium-67 citrate (/sup 67/Ga) accumulation and various enzyme activities during the repair of rat heart with infarct-like lesions induced by isoproterenol (ISP) treatment were measured for 10 days after treatment. Serum creatine phosphokinase (CPK) and glutamic oxalacetic transaminase (GOT) activities were increased immediately after ISP treatment, reaching maximum levels of activity of 545+-64 U/ml and 542+-94 KU/ml, respectively, within 12 h. Uptake of /sup 67/Ga in the rat heart was elevated 12 h after ISP treatment, reaching a maximum on day 1 (0.267+-0.020% dose/g heart). This pattern was essentially similar to the pattern of uronic acid content in the 1.2 M NaCl fraction, which contained mainly heparan sulfate (HS). The activity of glucose-6-phosphate dehydrogenase (G-6-PDH), a marker enzyme for fibrogenesis of damaged tissues, was also elevated 12 h after the ISP treatment, reaching a maximum of approximately 2.47 times that of the control heart on day 1. On the other hand, there were no significant changes in the /sup 67/Ga uptake and uronic acid content in any of the fractions of the liver and kidneys. These findings suggested that HS might be an acceptor for /sup 67/Ga accumulation during the repair of rat heart with infarct-like lesions, in accord with  More>>
Publication Date:
Dec 01, 1982
Product Type:
Journal Article
Reference Number:
EDB-83-060755
Resource Relation:
Journal Name: Eur. J. Nucl. Med.; (Germany, Federal Republic of); Journal Volume: 7:12
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; GALLIUM 67; UPTAKE; HEART; BIOLOGICAL REPAIR; ENZYME ACTIVITY; AMINOTRANSFERASES; CARDIOVASCULAR DISEASES; CITRATES; DRUGS; GALLIUM COMPOUNDS; KIDNEYS; LIVER; OXIDOREDUCTASES; PHOSPHOTRANSFERASES; RADIOPHARMACEUTICALS; RATS; ANIMALS; BETA DECAY RADIOISOTOPES; BIOLOGICAL RECOVERY; BODY; CARBOXYLIC ACID SALTS; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; ENZYMES; GALLIUM ISOTOPES; GLANDS; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; NITROGEN TRANSFERASES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PHOSPHORUS-GROUP TRANSFERASES; RADIOISOTOPES; RECOVERY; REPAIR; RODENTS; TRANSFERASES; VERTEBRATES; 560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
OSTI ID:
6514307
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EJNMD
Submitting Site:
HEDB
Size:
Pages: 545-548
Announcement Date:
Jan 01, 1983

Journal Article:

Citation Formats

Sasaki, T, Kojima, S, and Kubodera, A. Uptake of /sup 67/Ga in the heart of rats treated with isoproterenol. Germany: N. p., 1982. Web.
Sasaki, T, Kojima, S, & Kubodera, A. Uptake of /sup 67/Ga in the heart of rats treated with isoproterenol. Germany.
Sasaki, T, Kojima, S, and Kubodera, A. 1982. "Uptake of /sup 67/Ga in the heart of rats treated with isoproterenol." Germany.
@misc{etde_6514307,
title = {Uptake of /sup 67/Ga in the heart of rats treated with isoproterenol}
author = {Sasaki, T, Kojima, S, and Kubodera, A}
abstractNote = {Gallium-67 citrate (/sup 67/Ga) accumulation and various enzyme activities during the repair of rat heart with infarct-like lesions induced by isoproterenol (ISP) treatment were measured for 10 days after treatment. Serum creatine phosphokinase (CPK) and glutamic oxalacetic transaminase (GOT) activities were increased immediately after ISP treatment, reaching maximum levels of activity of 545+-64 U/ml and 542+-94 KU/ml, respectively, within 12 h. Uptake of /sup 67/Ga in the rat heart was elevated 12 h after ISP treatment, reaching a maximum on day 1 (0.267+-0.020% dose/g heart). This pattern was essentially similar to the pattern of uronic acid content in the 1.2 M NaCl fraction, which contained mainly heparan sulfate (HS). The activity of glucose-6-phosphate dehydrogenase (G-6-PDH), a marker enzyme for fibrogenesis of damaged tissues, was also elevated 12 h after the ISP treatment, reaching a maximum of approximately 2.47 times that of the control heart on day 1. On the other hand, there were no significant changes in the /sup 67/Ga uptake and uronic acid content in any of the fractions of the liver and kidneys. These findings suggested that HS might be an acceptor for /sup 67/Ga accumulation during the repair of rat heart with infarct-like lesions, in accord with our previous results on CCl/sub 4/-damaged rat liver.}
journal = {Eur. J. Nucl. Med.; (Germany, Federal Republic of)}
volume = {7:12}
journal type = {AC}
place = {Germany}
year = {1982}
month = {Dec}
}