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Myelin basic protein in brains of rats with low dose lead encephalopathy

Journal Article:

Abstract

In the present study control rats and lead exposed rats which did not have any retardation of growth were examined by radioimmunological assay of myelin basic protein (MBP) of homogenates of cerebrum and cerebellum at 30, 60 and 120 days of age. Lead was administered on postnatal days 1-15 by daily intraperitoneal injections of 10 mg lead nitrate/kg body weight. This lead dose results in light microscopically discernible hemorrhagic encephalopathy in the cerebellum of 15-day old rats, but does not induce growth retardation. The controls were injected with vehicle only. The amount of lead in the blood and brain homogenates of lead-exposed and control rats 15-200 days old was estimated by atomic absorption spectrophotometry. Significant differences between the lead-exposed and control rats were not found in the cerebral or cerebellar content of MBP. Considering the results of previous investigations, the findings do not exclude a hypo-myelinating effect of lead, but they suggest that exposure to lead without concomitant malnutrition does not cause hypo-myelination in the cerebrum and cerebellum of the developing rat.
Publication Date:
Feb 01, 1987
Product Type:
Journal Article
Reference Number:
DE-87-007625; EDB-87-098974
Resource Relation:
Journal Name: Arch. Toxicol.; (Germany, Federal Republic of); Journal Volume: 59:5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LEAD NITRATES; BIOLOGICAL EFFECTS; BRAIN; ANIMAL GROWTH; BLOOD; HOMOGENATES; INTRAPERITONEAL INJECTION; MYELIN; NEONATES; NERVOUS SYSTEM DISEASES; PATHOLOGICAL CHANGES; QUANTITY RATIO; RADIOIMMUNOASSAY; RATS; WEIGHT; ANIMALS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CELL CONSTITUENTS; CELL MEMBRANES; CENTRAL NERVOUS SYSTEM; DISEASES; GROWTH; IMMUNOASSAY; IMMUNOLOGY; INJECTION; INTAKE; ISOTOPE APPLICATIONS; LEAD COMPOUNDS; MAMMALS; MATERIALS; MEMBRANES; NERVOUS SYSTEM; NITRATES; NITROGEN COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; RADIOASSAY; RADIOIMMUNOLOGY; RODENTS; TRACER TECHNIQUES; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology
OSTI ID:
6513913
Research Organizations:
Goeteborg Univ., Sweden. Div. of Neuropathology; St. Joergens Hospital, Hisings Backa, Sweden
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ARTOD
Submitting Site:
DE
Size:
Pages: 341-345
Announcement Date:

Journal Article:

Citation Formats

Sundstroem, R, and Karlsson, B. Myelin basic protein in brains of rats with low dose lead encephalopathy. Germany: N. p., 1987. Web.
Sundstroem, R, & Karlsson, B. Myelin basic protein in brains of rats with low dose lead encephalopathy. Germany.
Sundstroem, R, and Karlsson, B. 1987. "Myelin basic protein in brains of rats with low dose lead encephalopathy." Germany.
@misc{etde_6513913,
title = {Myelin basic protein in brains of rats with low dose lead encephalopathy}
author = {Sundstroem, R, and Karlsson, B}
abstractNote = {In the present study control rats and lead exposed rats which did not have any retardation of growth were examined by radioimmunological assay of myelin basic protein (MBP) of homogenates of cerebrum and cerebellum at 30, 60 and 120 days of age. Lead was administered on postnatal days 1-15 by daily intraperitoneal injections of 10 mg lead nitrate/kg body weight. This lead dose results in light microscopically discernible hemorrhagic encephalopathy in the cerebellum of 15-day old rats, but does not induce growth retardation. The controls were injected with vehicle only. The amount of lead in the blood and brain homogenates of lead-exposed and control rats 15-200 days old was estimated by atomic absorption spectrophotometry. Significant differences between the lead-exposed and control rats were not found in the cerebral or cerebellar content of MBP. Considering the results of previous investigations, the findings do not exclude a hypo-myelinating effect of lead, but they suggest that exposure to lead without concomitant malnutrition does not cause hypo-myelination in the cerebrum and cerebellum of the developing rat.}
journal = {Arch. Toxicol.; (Germany, Federal Republic of)}
volume = {59:5}
journal type = {AC}
place = {Germany}
year = {1987}
month = {Feb}
}