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Radioimmunoassay and some properties of human antibodies to hepatitis B core antigen

Journal Article:

Abstract

A solid-phase radioimmunoassay for antibodies to hepatitis B core antigen (anti-HBsub(c)) is described. Polystyrene beads coated with anti-HBsub(c), hepatitis B core antigen prepared from pooled sera of humans infected with hepatitis B virus (HBV) and /sup 125/I-labelled anti-HBsub(c) were used for the test. Distinct patterns of development and changes of anti-HBsub(c) and their immunological properties are all related to variations of other markers specific for HBV infections. Knowledge concerning the detailed features of the immune response to hepatitis B core antigen may provide deeper insight into the pathogenesis of HBV infections.
Authors:
Neurath, A R; Szmuness, W; Stevens, C E; Strick, N; Harley, E J [1] 
  1. New York Blood Center, N.Y. (USA)
Publication Date:
Mar 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-09-401710; EDB-79-038825
Resource Relation:
Journal Name: J. Gen. Virol.; (United Kingdom); Journal Volume: 38:3
Subject:
59 BASIC BIOLOGICAL SCIENCES; ANTIGENS; RADIOIMMUNOASSAY; HEPATITIS; ANTIGEN-ANTIBODY REACTIONS; ANTIBODIES; BLOOD SERUM; IMMUNE REACTIONS; INFECTIOUS DISEASES; IODINE 125; LABELLING; PATIENTS; SENSITIVITY; SPECIFICITY; TIME DEPENDENCE; VIRUSES; BETA DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM DISEASES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MICROORGANISMS; NUCLEI; ODD-EVEN NUCLEI; PARASITES; RADIOASSAY; RADIOISOTOPES; TRACER TECHNIQUES; 550201* - Biochemistry- Tracer Techniques; 550901 - Pathology- Tracer Techniques
OSTI ID:
6510971
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JGVIA
Submitting Site:
INIS
Size:
Pages: 549-559
Announcement Date:

Journal Article:

Citation Formats

Neurath, A R, Szmuness, W, Stevens, C E, Strick, N, and Harley, E J. Radioimmunoassay and some properties of human antibodies to hepatitis B core antigen. United Kingdom: N. p., 1978. Web.
Neurath, A R, Szmuness, W, Stevens, C E, Strick, N, & Harley, E J. Radioimmunoassay and some properties of human antibodies to hepatitis B core antigen. United Kingdom.
Neurath, A R, Szmuness, W, Stevens, C E, Strick, N, and Harley, E J. 1978. "Radioimmunoassay and some properties of human antibodies to hepatitis B core antigen." United Kingdom.
@misc{etde_6510971,
title = {Radioimmunoassay and some properties of human antibodies to hepatitis B core antigen}
author = {Neurath, A R, Szmuness, W, Stevens, C E, Strick, N, and Harley, E J}
abstractNote = {A solid-phase radioimmunoassay for antibodies to hepatitis B core antigen (anti-HBsub(c)) is described. Polystyrene beads coated with anti-HBsub(c), hepatitis B core antigen prepared from pooled sera of humans infected with hepatitis B virus (HBV) and /sup 125/I-labelled anti-HBsub(c) were used for the test. Distinct patterns of development and changes of anti-HBsub(c) and their immunological properties are all related to variations of other markers specific for HBV infections. Knowledge concerning the detailed features of the immune response to hepatitis B core antigen may provide deeper insight into the pathogenesis of HBV infections.}
journal = {J. Gen. Virol.; (United Kingdom)}
volume = {38:3}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Mar}
}