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Cytogenetics of acute leukaemia

Journal Article:

Abstract

The study of chromosomal abnormalities in patients with acute leukemia, begun just 20 years ago, has provided haematologists with new insights into the nature of this disease. It soon became evident that the modal chromosomal number and the chromosomal pattern (karyotype) appeared to be quite variable. Moreover, a number of patients appeared to have a normal karyotype. The early studies were frequently carried out using mitogen-stimulated peripheral blood cells, and one could argue that the analysis was not based on the leukemic cells. Since many of the patients with abnormalities were examined prior to treatment, the aberrations were not induced by therapy. It was noted quite early that the morphology of chromosomes from the leukemic cells was very fuzzy as compared with the chromosomes from the normal marrow cells. The reason for the poor morphology is still not understood. The results of chromosomal analysis of bone marrow-derived cells obtained from patients with acute leukemia appear to have prognostic significance, although this information is not currently being used in making decisions regarding the treatment of individual patients. The data from analyses with banding techniques reveal that there are non-random patterns of abnormalities, which supports the concept proposed by Boveri in 1914  More>>
Authors:
Publication Date:
Jun 01, 1978
Product Type:
Journal Article
Reference Number:
EDB-79-027607
Resource Relation:
Journal Name: Clin. Haematol.; (United Kingdom); Journal Volume: 7:2
Subject:
59 BASIC BIOLOGICAL SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; LEUKEMIA; CHROMOSOMAL ABERRATIONS; MYELOID LEUKEMIA; BIOLOGICAL INDICATORS; BONE MARROW; CLONE CELLS; CYTOLOGY; KARYOTYPE; MORPHOLOGY; BIOLOGY; BODY; CELL CULTURES; DISEASES; HEMATOPOIETIC SYSTEM; HEMIC DISEASES; MUTATIONS; NEOPLASMS; ORGANS; TISSUES; 550400* - Genetics; 550300 - Cytology; 550600 - Medicine; 551000 - Physiological Systems
OSTI ID:
6504956
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CLHMB
Submitting Site:
TIC
Size:
Pages: 385-406
Announcement Date:
Mar 01, 1979

Journal Article:

Citation Formats

Rowley, J D. Cytogenetics of acute leukaemia. United Kingdom: N. p., 1978. Web.
Rowley, J D. Cytogenetics of acute leukaemia. United Kingdom.
Rowley, J D. 1978. "Cytogenetics of acute leukaemia." United Kingdom.
@misc{etde_6504956,
title = {Cytogenetics of acute leukaemia}
author = {Rowley, J D}
abstractNote = {The study of chromosomal abnormalities in patients with acute leukemia, begun just 20 years ago, has provided haematologists with new insights into the nature of this disease. It soon became evident that the modal chromosomal number and the chromosomal pattern (karyotype) appeared to be quite variable. Moreover, a number of patients appeared to have a normal karyotype. The early studies were frequently carried out using mitogen-stimulated peripheral blood cells, and one could argue that the analysis was not based on the leukemic cells. Since many of the patients with abnormalities were examined prior to treatment, the aberrations were not induced by therapy. It was noted quite early that the morphology of chromosomes from the leukemic cells was very fuzzy as compared with the chromosomes from the normal marrow cells. The reason for the poor morphology is still not understood. The results of chromosomal analysis of bone marrow-derived cells obtained from patients with acute leukemia appear to have prognostic significance, although this information is not currently being used in making decisions regarding the treatment of individual patients. The data from analyses with banding techniques reveal that there are non-random patterns of abnormalities, which supports the concept proposed by Boveri in 1914 that chromosomal aberrations are among the fundamental changes associated with malignancy. The acute non-lymphocytic leukemias (ANLL) of adults are one of the most thoroughly studied of human malignancies. Presentation of the results of cytogenetic analysis with banding of myeloid cells from these patients forms the major portion of this chapter. Recent reports on banding studies in acute lymphocytic leukemia (ALL) will be discussed and results will be compared with ANLL. Although there are very few data on the karyotypes of leukemia occurring as a second malignancy, the abnormalities seen show some distinct differences from ANLL that arises de novo.}
journal = {Clin. Haematol.; (United Kingdom)}
volume = {7:2}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Jun}
}