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Enhanced spermatogonial stem cell killing and reduced translocation yield from X-irradiated 101/H mice

Journal Article:

Abstract

The spermatogonial stem cells of 101/H mice have been found to be more sensitive to killing by acute X-ray doses than those of the 'standard' C3H/HeH x 101/H F/sub 1/ hybrid. Duration of the sterile period was longer throughout the 0.5-8.0-Gy dose range tested and 'recovered' testis weights, taken after recovery of fertility, were more severely reduced. The shapes of the sterile period dose-response curves were similar, but with the 101/H mice the plateau occurred at 3-5 Gy, rather than at 6 Gy. An equivalent observation was made with the testis weight data. The translocation dose-response curve was bell-shaped, as previously found with the hybrid, but yields were lower at all but the lowest doses. Notably, peak yields occurred at 3-5 Gy, rather than at 6 Gy. The altered stem cell killing and genetic responses may be explained either by a higher proportion of radiosensitive cells in the heterogeneous stem cell population or by a higher ratio of cell killing to recoverable chromosome damage which might imply a reduced repair capacity. (Auth.). 43 refs.; 5 figs.; 5 tabs.
Publication Date:
Jan 01, 1987
Product Type:
Journal Article
Reference Number:
AIX-18-056051; EDB-87-112552
Resource Relation:
Journal Name: Mutat. Res.; (Netherlands); Journal Volume: 176:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MICE; GENETIC RADIATION EFFECTS; SPERMATOGONIA; CHROMOSOMAL ABERRATIONS; DOSE-RESPONSE RELATIONSHIPS; LETHAL IRRADIATION; STEM CELLS; STERILITY; TESTES; X RADIATION; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; ELECTROMAGNETIC RADIATION; GAMETES; GENETIC EFFECTS; GERM CELLS; GONADS; IONIZING RADIATIONS; IRRADIATION; MALE GENITALS; MAMMALS; MUTATIONS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture
OSTI ID:
6498660
Research Organizations:
Medical Research Council, Chilton, UK. Radiobiology Unit
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: MUREA
Submitting Site:
INIS
Size:
Pages: 69-79
Announcement Date:

Journal Article:

Citation Formats

Cattanach, B M, and Kirk, M J. Enhanced spermatogonial stem cell killing and reduced translocation yield from X-irradiated 101/H mice. Netherlands: N. p., 1987. Web.
Cattanach, B M, & Kirk, M J. Enhanced spermatogonial stem cell killing and reduced translocation yield from X-irradiated 101/H mice. Netherlands.
Cattanach, B M, and Kirk, M J. 1987. "Enhanced spermatogonial stem cell killing and reduced translocation yield from X-irradiated 101/H mice." Netherlands.
@misc{etde_6498660,
title = {Enhanced spermatogonial stem cell killing and reduced translocation yield from X-irradiated 101/H mice}
author = {Cattanach, B M, and Kirk, M J}
abstractNote = {The spermatogonial stem cells of 101/H mice have been found to be more sensitive to killing by acute X-ray doses than those of the 'standard' C3H/HeH x 101/H F/sub 1/ hybrid. Duration of the sterile period was longer throughout the 0.5-8.0-Gy dose range tested and 'recovered' testis weights, taken after recovery of fertility, were more severely reduced. The shapes of the sterile period dose-response curves were similar, but with the 101/H mice the plateau occurred at 3-5 Gy, rather than at 6 Gy. An equivalent observation was made with the testis weight data. The translocation dose-response curve was bell-shaped, as previously found with the hybrid, but yields were lower at all but the lowest doses. Notably, peak yields occurred at 3-5 Gy, rather than at 6 Gy. The altered stem cell killing and genetic responses may be explained either by a higher proportion of radiosensitive cells in the heterogeneous stem cell population or by a higher ratio of cell killing to recoverable chromosome damage which might imply a reduced repair capacity. (Auth.). 43 refs.; 5 figs.; 5 tabs.}
journal = {Mutat. Res.; (Netherlands)}
volume = {176:1}
journal type = {AC}
place = {Netherlands}
year = {1987}
month = {Jan}
}