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Synthetic medical studies on atomic bomb survivors exposed in short distances, 15. Detection of transforming gene(s)

Journal Article:

Abstract

In an effort to search for biological significance of chromosome aberration observed in bone marrow cells and peripheral lymphocytes, the presence of transforming genes in the DNA of bone marrow cells was examined in four healthy A-bomb survivors (Group I), three with preleukemia (Group II), and nine with leukemia (Group III). In Group I exposed at 300 - 500 m from the hypocenter, estimated radiation doses ranged from 565 to 667 cGy; and randomly abnormal karyotypes ranged from 30.7 % to 48.3 %. In Group II exposed at 800 m, in which estimated radiation doses were 300 - 600 cGy, one survivor had a complicated karyotype abnormality; and in the two others, abnormal clones were partly observed. Group III, which was exposed at 800 - 2,000 m and had estimated doses of 20 - 200 cGy, consisted of acute lymphoid leukemia (one), acute myeloid leukemia (five), and chronic myeloid leukemia (three). The patient with acute lymphoid leukemia had a complicated karyotype abnormality. N-ras genes were observed not only in seven acute or chronic leukemic patients but also in three healthy survivors. This may have important implications for the mechanism of leukemic transformation. (Namekawa, K.).
Publication Date:
Mar 01, 1988
Product Type:
Journal Article
Reference Number:
JPN-89-003238; EDB-89-042683
Resource Relation:
Journal Name: Hiroshima Igaku; (Japan); Journal Volume: 41:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; GENES; ONCOGENIC TRANSFORMATIONS; BONE MARROW CELLS; CELL CULTURES; CHROMOSOMAL ABERRATIONS; DISTANCE; DNA; LEUKEMIA; RADIATION DOSES; ANIMAL CELLS; CELL TRANSFORMATIONS; CONNECTIVE TISSUE CELLS; DISEASES; DOSES; HEMIC DISEASES; HUMAN POPULATIONS; IMMUNE SYSTEM DISEASES; MUTATIONS; NEOPLASMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; POPULATIONS; SOMATIC CELLS; 560151* - Radiation Effects on Animals- Man
OSTI ID:
6496940
Research Organizations:
Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: HIRGA
Submitting Site:
JPN
Size:
Pages: 440-444
Announcement Date:

Journal Article:

Citation Formats

Kamada, Nanao, Tanaka, Kimio, Kontani, Nobuko, Yokoro, Kenjiro, Takimoto, Yasuo, Kuramoto, Atsushi, Munaka, Masaki, Kurihara, Minoru, and Hattori, Takao. Synthetic medical studies on atomic bomb survivors exposed in short distances, 15. Detection of transforming gene(s). Japan: N. p., 1988. Web.
Kamada, Nanao, Tanaka, Kimio, Kontani, Nobuko, Yokoro, Kenjiro, Takimoto, Yasuo, Kuramoto, Atsushi, Munaka, Masaki, Kurihara, Minoru, & Hattori, Takao. Synthetic medical studies on atomic bomb survivors exposed in short distances, 15. Detection of transforming gene(s). Japan.
Kamada, Nanao, Tanaka, Kimio, Kontani, Nobuko, Yokoro, Kenjiro, Takimoto, Yasuo, Kuramoto, Atsushi, Munaka, Masaki, Kurihara, Minoru, and Hattori, Takao. 1988. "Synthetic medical studies on atomic bomb survivors exposed in short distances, 15. Detection of transforming gene(s)." Japan.
@misc{etde_6496940,
title = {Synthetic medical studies on atomic bomb survivors exposed in short distances, 15. Detection of transforming gene(s)}
author = {Kamada, Nanao, Tanaka, Kimio, Kontani, Nobuko, Yokoro, Kenjiro, Takimoto, Yasuo, Kuramoto, Atsushi, Munaka, Masaki, Kurihara, Minoru, and Hattori, Takao}
abstractNote = {In an effort to search for biological significance of chromosome aberration observed in bone marrow cells and peripheral lymphocytes, the presence of transforming genes in the DNA of bone marrow cells was examined in four healthy A-bomb survivors (Group I), three with preleukemia (Group II), and nine with leukemia (Group III). In Group I exposed at 300 - 500 m from the hypocenter, estimated radiation doses ranged from 565 to 667 cGy; and randomly abnormal karyotypes ranged from 30.7 % to 48.3 %. In Group II exposed at 800 m, in which estimated radiation doses were 300 - 600 cGy, one survivor had a complicated karyotype abnormality; and in the two others, abnormal clones were partly observed. Group III, which was exposed at 800 - 2,000 m and had estimated doses of 20 - 200 cGy, consisted of acute lymphoid leukemia (one), acute myeloid leukemia (five), and chronic myeloid leukemia (three). The patient with acute lymphoid leukemia had a complicated karyotype abnormality. N-ras genes were observed not only in seven acute or chronic leukemic patients but also in three healthy survivors. This may have important implications for the mechanism of leukemic transformation. (Namekawa, K.).}
journal = {Hiroshima Igaku; (Japan)}
volume = {41:3}
journal type = {AC}
place = {Japan}
year = {1988}
month = {Mar}
}