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Histopathological studies on the irradiated brain tumors

Journal Article:

Abstract

Of 43 cases of irradiated brain tumor, histological findings showed extensive necrosis or disappearance of the neoplasm, considered to be attributable to radiation treatment, in 30 (70%). Extensive necrosis of the tumor in areas exposed to radiation was found in 16 treated cases (37.2%). The histopathology of massive necrosis was that of simple coagulative necrosis, sometimes with marked vascular alterations and extravasation of fibrinoid material into the necrotic tissue. Necrosis was almost always incomplete, and foci of residual tumors were found at the periphery of the tumors. The terminal picture in cases of massive necrosis was often that of widespread intra- and extracranial metastasis. Almost complete disappearance of the tumor was observed in some cases with subsequent diffuse degenerative changes in the brain parenchyma exposed to radiation. In 5 cases of irradiated tumors, autopsy findings suggested that the growth of the primary tumor might have been restricted. And in 5 cases tumor cytology revealed the marked presence of a large number of multinucleated, bizarre giant cells with evidence of degeneration in both the cytoplasm and the nucleus. Multifocal necrosis of the brain, with axonal swelling and sponginess of the tissue, was observed in two patients following combined radiation and antineoplastic  More>>
Authors:
Narita, T [1] 
  1. Gunma Univ., Maebashi (Japan).School of Medicine
Publication Date:
Jan 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-12-601969; EDB-81-064585
Resource Relation:
Journal Name: Kitakanto Igaku; (Japan); Journal Volume: 29:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BRAIN; BIOLOGICAL RADIATION EFFECTS; RADIOTHERAPY; SIDE EFFECTS; AUTOPSY; CARCINOMAS; CEREBELLUM; CEREBRUM; ENCEPHALITIS; FRACTIONATED IRRADIATION; LYMPHOMAS; METASTASES; NECROSIS; PATIENTS; PINEAL GLAND; X RADIATION; BIOLOGICAL EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTROMAGNETIC RADIATION; GLANDS; INFECTIOUS DISEASES; IONIZING RADIATIONS; IRRADIATION; MEDICINE; NEOPLASMS; NERVOUS SYSTEM; NERVOUS SYSTEM DISEASES; NUCLEAR MEDICINE; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIATIONS; RADIOLOGY; THERAPY; VIRAL DISEASES; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
6461331
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: KKAIA
Submitting Site:
INIS
Size:
Pages: 201-221
Announcement Date:
May 01, 1981

Journal Article:

Citation Formats

Narita, T. Histopathological studies on the irradiated brain tumors. Japan: N. p., 1980. Web.
Narita, T. Histopathological studies on the irradiated brain tumors. Japan.
Narita, T. 1980. "Histopathological studies on the irradiated brain tumors." Japan.
@misc{etde_6461331,
title = {Histopathological studies on the irradiated brain tumors}
author = {Narita, T}
abstractNote = {Of 43 cases of irradiated brain tumor, histological findings showed extensive necrosis or disappearance of the neoplasm, considered to be attributable to radiation treatment, in 30 (70%). Extensive necrosis of the tumor in areas exposed to radiation was found in 16 treated cases (37.2%). The histopathology of massive necrosis was that of simple coagulative necrosis, sometimes with marked vascular alterations and extravasation of fibrinoid material into the necrotic tissue. Necrosis was almost always incomplete, and foci of residual tumors were found at the periphery of the tumors. The terminal picture in cases of massive necrosis was often that of widespread intra- and extracranial metastasis. Almost complete disappearance of the tumor was observed in some cases with subsequent diffuse degenerative changes in the brain parenchyma exposed to radiation. In 5 cases of irradiated tumors, autopsy findings suggested that the growth of the primary tumor might have been restricted. And in 5 cases tumor cytology revealed the marked presence of a large number of multinucleated, bizarre giant cells with evidence of degeneration in both the cytoplasm and the nucleus. Multifocal necrosis of the brain, with axonal swelling and sponginess of the tissue, was observed in two patients following combined radiation and antineoplastic chemotherapy. Diffuse loss and degeneration of nerve cells of the cerebral cortex in pseudo-laminar fashion was observed in 7 patients with or without bilateral necrosis of the globus pallidus. Histological findings revealed typical anoxic encephalopathy.}
journal = {Kitakanto Igaku; (Japan)}
volume = {29:4}
journal type = {AC}
place = {Japan}
year = {1980}
month = {Jan}
}