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Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytostatic drugs, and other potential hazards in hospitals, based on registered information of outcome

Abstract

Nurses working in selected departments of general hospitals in Finland were collected from a central register on health personnel in Finland. Using the Hospital Discharge Register and the Register of Congenital Malformations, case nurses were selected who had had a spontaneous abortion (N = 217) or a malformed child (N = 46) between the years 1973 and 1979. Controls consisted of three nurses who had had a normal birth; the control nurses were matched for age and hospital of employment. Information on exposure in the first trimester of pregnancy was sought through the head nurses of the hospitals. No significant increase in risk of spontaneous abortion or of malformation was observed after exposure to anaesthetic gases (odds ratio for spontaneous abortion 1.2), sterilizing gases and soaps, or x-rays. Handling of cytostatic drugs did not affect the frequency of spontaneous abortion but was associated with malformations in the offspring. The odds ratio, based on eight cases, was 4.7 (p = 0.02) when the logistic model was adopted. The results suggest that the exposures investigated, other than cytostatic drugs, do not cause a strong reproductive risk. Further studies are needed, particularly on cytostatic drugs.
Publication Date:
Jun 01, 1985
Product Type:
Journal Article
Reference Number:
NLM-85-36089; EDB-86-011492
Resource Relation:
Journal Name: J. Epidemiol. Community Health; (United Kingdom); Journal Volume: 2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANESTHETICS; HEALTH HAZARDS; DISINFECTANTS; FORMALDEHYDE; MEDICAL PERSONNEL; DELAYED RADIATION EFFECTS; PROGENY; ABORTION; MALFORMATIONS; ENVIRONMENTAL EXPOSURE; FINLAND; INFORMATION NEEDS; MATHEMATICAL MODELS; PREGNANCY; RISK ASSESSMENT; ALDEHYDES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DRUGS; EUROPE; GERMICIDES; HAZARDS; ORGANIC COMPOUNDS; PATHOLOGICAL CHANGES; PERSONNEL; RADIATION EFFECTS; SCANDINAVIA; WESTERN EUROPE; 560151* - Radiation Effects on Animals- Man; 560306 - Chemicals Metabolism & Toxicology- Man- (-1987)
OSTI ID:
6452390
Research Organizations:
Institute of Occupational Health, Helsinki, Finland
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JECHD
Submitting Site:
HEDB
Size:
Pages: 141-147
Announcement Date:

Citation Formats

Hemminki, K, Kyyroenen, P L, and Lindbohm, M L. Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytostatic drugs, and other potential hazards in hospitals, based on registered information of outcome. United Kingdom: N. p., 1985. Web. doi:10.1136/jech.39.2.141.
Hemminki, K, Kyyroenen, P L, & Lindbohm, M L. Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytostatic drugs, and other potential hazards in hospitals, based on registered information of outcome. United Kingdom. doi:10.1136/jech.39.2.141.
Hemminki, K, Kyyroenen, P L, and Lindbohm, M L. 1985. "Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytostatic drugs, and other potential hazards in hospitals, based on registered information of outcome." United Kingdom. doi:10.1136/jech.39.2.141. https://www.osti.gov/servlets/purl/10.1136/jech.39.2.141.
@misc{etde_6452390,
title = {Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytostatic drugs, and other potential hazards in hospitals, based on registered information of outcome}
author = {Hemminki, K, Kyyroenen, P L, and Lindbohm, M L}
abstractNote = {Nurses working in selected departments of general hospitals in Finland were collected from a central register on health personnel in Finland. Using the Hospital Discharge Register and the Register of Congenital Malformations, case nurses were selected who had had a spontaneous abortion (N = 217) or a malformed child (N = 46) between the years 1973 and 1979. Controls consisted of three nurses who had had a normal birth; the control nurses were matched for age and hospital of employment. Information on exposure in the first trimester of pregnancy was sought through the head nurses of the hospitals. No significant increase in risk of spontaneous abortion or of malformation was observed after exposure to anaesthetic gases (odds ratio for spontaneous abortion 1.2), sterilizing gases and soaps, or x-rays. Handling of cytostatic drugs did not affect the frequency of spontaneous abortion but was associated with malformations in the offspring. The odds ratio, based on eight cases, was 4.7 (p = 0.02) when the logistic model was adopted. The results suggest that the exposures investigated, other than cytostatic drugs, do not cause a strong reproductive risk. Further studies are needed, particularly on cytostatic drugs.}
doi = {10.1136/jech.39.2.141}
journal = {J. Epidemiol. Community Health; (United Kingdom)}
volume = {2}
journal type = {AC}
place = {United Kingdom}
year = {1985}
month = {Jun}
}