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Chronic dihydroergotoxine treatment affects the number of dopamine recognition sites in rat striatum

Abstract

Ergot derivatives have been proposed to have ameliorative effects in various pathological conditions where dopaminergic transmission is believed to be impaired, namely Parkinson's disease, amenorrhea-galactorrhea syndrome, and in the treatment of behavioural disturbances of the elderly. To get more insight into a possible involvement of a direct action of ergot derivatives on dopamine receptors we studied the effect of acute and chronic dihydroergotoxine (DHT) treatment on 3H-Spiroperidol and 3H-N-Propylnorapomorphine (3H-NPA) binding to rat striatal membrane preparations. The results are in favor of an interaction of ergot derivatives with dopamine recognition sites both after acute and chronic treatment.
Publication Date:
Jun 01, 1984
Product Type:
Journal Article
Reference Number:
EDB-84-170234
Resource Relation:
Journal Name: Pharmacol. Res. Commun.; (United Kingdom); Journal Volume: 16:6
Subject:
59 BASIC BIOLOGICAL SCIENCES; DOPAMINE; RECEPTORS; BRAIN; CHEMICAL BONDS; DRUGS; NERVOUS SYSTEM DISEASES; TRACER TECHNIQUES; TRITIUM COMPOUNDS; AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; DISEASES; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; SYMPATHOMIMETICS; 550201* - Biochemistry- Tracer Techniques
OSTI ID:
6441301
Research Organizations:
Inst. of Pharmacology and Pharmacognosy, University of Milan
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PLRCA
Submitting Site:
HEDB
Size:
Pages: 605-611
Announcement Date:

Citation Formats

Battaini, F, Govoni, S, Rius, R A, Spano, P F, and Trabucchi, M. Chronic dihydroergotoxine treatment affects the number of dopamine recognition sites in rat striatum. United Kingdom: N. p., 1984. Web. doi:10.1016/S0031-6989(84)80040-5.
Battaini, F, Govoni, S, Rius, R A, Spano, P F, & Trabucchi, M. Chronic dihydroergotoxine treatment affects the number of dopamine recognition sites in rat striatum. United Kingdom. doi:10.1016/S0031-6989(84)80040-5.
Battaini, F, Govoni, S, Rius, R A, Spano, P F, and Trabucchi, M. 1984. "Chronic dihydroergotoxine treatment affects the number of dopamine recognition sites in rat striatum." United Kingdom. doi:10.1016/S0031-6989(84)80040-5. https://www.osti.gov/servlets/purl/10.1016/S0031-6989(84)80040-5.
@misc{etde_6441301,
title = {Chronic dihydroergotoxine treatment affects the number of dopamine recognition sites in rat striatum}
author = {Battaini, F, Govoni, S, Rius, R A, Spano, P F, and Trabucchi, M}
abstractNote = {Ergot derivatives have been proposed to have ameliorative effects in various pathological conditions where dopaminergic transmission is believed to be impaired, namely Parkinson's disease, amenorrhea-galactorrhea syndrome, and in the treatment of behavioural disturbances of the elderly. To get more insight into a possible involvement of a direct action of ergot derivatives on dopamine receptors we studied the effect of acute and chronic dihydroergotoxine (DHT) treatment on 3H-Spiroperidol and 3H-N-Propylnorapomorphine (3H-NPA) binding to rat striatal membrane preparations. The results are in favor of an interaction of ergot derivatives with dopamine recognition sites both after acute and chronic treatment.}
doi = {10.1016/S0031-6989(84)80040-5}
journal = {Pharmacol. Res. Commun.; (United Kingdom)}
volume = {16:6}
journal type = {AC}
place = {United Kingdom}
year = {1984}
month = {Jun}
}