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Distribution of mercury in the brain and its subcellular units in experimental organic mercury poisonings

Journal Article:

Abstract

The relation between mercury content and histological changes in dog brain was studied. The compounds used were methylmercury thioacetamide (CH/sub 3/HgSCH/sub 2/CONH/sub 2/) with and without /sup 203/Hg. The most noticeable histological change was observed in the calcarine area where the mercury level was always higher than in other areas. In some dogs the mercury content in the cerebellum was noticeably high, but this was not a constant finding. Chemical fractionation of the brain of the rat poisoned with the radioactive methylmercury compound revealed that almost all radioactivity resided in the protein fraction, there being little radioactivity in the lipid and nucleic acid fractions. Hydrolysis of the protein released mercury. It is noteworthy that a latent period exists between the time when the concentration of the poison in the brain reaches its peak and the development of nervous symptoms.
Publication Date:
Jan 01, 1966
Product Type:
Journal Article
Reference Number:
EDB-85-007333
Resource Relation:
Journal Name: J. Neurochem.; (United Kingdom); Journal Volume: 13
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MERCURY COMPOUNDS; BIOLOGICAL EFFECTS; BRAIN; CENTRAL NERVOUS SYSTEM; COMPARATIVE EVALUATIONS; DOGS; METHYLMERCURY; RATS; TISSUE DISTRIBUTION; TOXICITY; UPTAKE; VARIATIONS; ANIMALS; BODY; DISTRIBUTION; MAMMALS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANIC MERCURY COMPOUNDS; ORGANS; RODENTS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
6437848
Research Organizations:
Univ. of Tokyo, Japan
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JONRA
Submitting Site:
HEDB
Size:
Pages: 397-406
Announcement Date:

Journal Article:

Citation Formats

Yoshino, Y, Mozai, T, and Nakao, K. Distribution of mercury in the brain and its subcellular units in experimental organic mercury poisonings. United Kingdom: N. p., 1966. Web.
Yoshino, Y, Mozai, T, & Nakao, K. Distribution of mercury in the brain and its subcellular units in experimental organic mercury poisonings. United Kingdom.
Yoshino, Y, Mozai, T, and Nakao, K. 1966. "Distribution of mercury in the brain and its subcellular units in experimental organic mercury poisonings." United Kingdom.
@misc{etde_6437848,
title = {Distribution of mercury in the brain and its subcellular units in experimental organic mercury poisonings}
author = {Yoshino, Y, Mozai, T, and Nakao, K}
abstractNote = {The relation between mercury content and histological changes in dog brain was studied. The compounds used were methylmercury thioacetamide (CH/sub 3/HgSCH/sub 2/CONH/sub 2/) with and without /sup 203/Hg. The most noticeable histological change was observed in the calcarine area where the mercury level was always higher than in other areas. In some dogs the mercury content in the cerebellum was noticeably high, but this was not a constant finding. Chemical fractionation of the brain of the rat poisoned with the radioactive methylmercury compound revealed that almost all radioactivity resided in the protein fraction, there being little radioactivity in the lipid and nucleic acid fractions. Hydrolysis of the protein released mercury. It is noteworthy that a latent period exists between the time when the concentration of the poison in the brain reaches its peak and the development of nervous symptoms.}
journal = {J. Neurochem.; (United Kingdom)}
volume = {13}
journal type = {AC}
place = {United Kingdom}
year = {1966}
month = {Jan}
}