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Absence of photoreactivation of pyrimidine dimers in the epidermis of hairless mice following exposures to ultraviolet light

Journal Article:

Abstract

The influence of photoreactivating light on the fate of uv-induced DNA damage has been measured in the epidermis of hairless mice using damage-specific endonuclease from Micrococcus luteus. Groups of mice were exposed to varying fluences of uv at 297 nm or from an FS40 fluorescent sun lamp to induce uv photoproducts. The same fluence-dependent DNA damage was observed in high molecular weight epidermal DNA regardless of whether the mice were killed immediately, or maintained in the dark or under photorectivating light for 20 h after uv. Thus, no detectable photoreactivation of uv-induced pyrimidine dimers could be demonstrated in mouse epithelial cells in vivo.
Publication Date:
Jan 01, 1978
Product Type:
Journal Article
Reference Number:
ERA-04-028064; EDB-79-045100
Resource Relation:
Journal Name: Photochem. Photobiol.; (United Kingdom); Journal Volume: 27
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DIMERS; DNA; DAMAGE; PHOTOREACTIVATION; ULTRAVIOLET RADIATION; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CYTOLOGY; ENZYMES; EPIDERMIS; IN VIVO; MICE; PYRIMIDINES; ANIMALS; AZINES; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; BIOLOGY; BODY; ELECTROMAGNETIC RADIATION; EPITHELIUM; HETEROCYCLIC COMPOUNDS; MAMMALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RECOVERY; REPAIR; RODENTS; SKIN; TISSUES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6432351
Research Organizations:
Argonne National Lab., IL
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PHCBA
Submitting Site:
ANL
Size:
Pages: 483-485
Announcement Date:

Journal Article:

Citation Formats

Ley, R D, Sedita, B A, and Grube, D D. Absence of photoreactivation of pyrimidine dimers in the epidermis of hairless mice following exposures to ultraviolet light. United Kingdom: N. p., 1978. Web.
Ley, R D, Sedita, B A, & Grube, D D. Absence of photoreactivation of pyrimidine dimers in the epidermis of hairless mice following exposures to ultraviolet light. United Kingdom.
Ley, R D, Sedita, B A, and Grube, D D. 1978. "Absence of photoreactivation of pyrimidine dimers in the epidermis of hairless mice following exposures to ultraviolet light." United Kingdom.
@misc{etde_6432351,
title = {Absence of photoreactivation of pyrimidine dimers in the epidermis of hairless mice following exposures to ultraviolet light}
author = {Ley, R D, Sedita, B A, and Grube, D D}
abstractNote = {The influence of photoreactivating light on the fate of uv-induced DNA damage has been measured in the epidermis of hairless mice using damage-specific endonuclease from Micrococcus luteus. Groups of mice were exposed to varying fluences of uv at 297 nm or from an FS40 fluorescent sun lamp to induce uv photoproducts. The same fluence-dependent DNA damage was observed in high molecular weight epidermal DNA regardless of whether the mice were killed immediately, or maintained in the dark or under photorectivating light for 20 h after uv. Thus, no detectable photoreactivation of uv-induced pyrimidine dimers could be demonstrated in mouse epithelial cells in vivo.}
journal = {Photochem. Photobiol.; (United Kingdom)}
volume = {27}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Jan}
}