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Further details of a hypothesis for the initiation of genetic recombination from recognition sites

Journal Article:

Abstract

Consideration of the initiation of genetic recombination from fixed sites recognised by an initiation complex, has provided more details of the envisaged mechanism and implications of a recent hypothesis. It has been shown that the hypothesis allows for more than one recombinogenic-event to result from a single binding of the recombination initiation complex to a recognition site in a DNA duplex. This capacity can explain data from fungal systems which are apparently inconsistent with the Meselson-Radding model of genetic recombination with respect to the positional relationship between tracts of hybrid DNA and sites of crossing-over. A mechanism for conversion, involving hybrid DNA formation, but without mismatch correction has also been proposed on the basis of this capacity. It is suggested that the hypothesis may apply generally to genetic recombination, in prokaryotes as well as eukaryotes.
Authors:
Markham, P [1] 
  1. Queen Elizabeth College, London (G.B.)
Publication Date:
Jan 01, 1982
Product Type:
Journal Article
Reference Number:
FR-83-00540; EDB-83-069549
Resource Relation:
Journal Name: Biomed. Pharmacother.; (France); Journal Volume: 36:3
Subject:
59 BASIC BIOLOGICAL SCIENCES; DNA; HYBRIDIZATION; GENE RECOMBINATION; CROSSING-OVER; STRAND BREAKS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; 550400* - Genetics
OSTI ID:
6430837
Country of Origin:
France
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BIPHE
Submitting Site:
HEDB
Size:
Pages: 128-133
Announcement Date:
Mar 01, 1983

Journal Article:

Citation Formats

Markham, P. Further details of a hypothesis for the initiation of genetic recombination from recognition sites. France: N. p., 1982. Web.
Markham, P. Further details of a hypothesis for the initiation of genetic recombination from recognition sites. France.
Markham, P. 1982. "Further details of a hypothesis for the initiation of genetic recombination from recognition sites." France.
@misc{etde_6430837,
title = {Further details of a hypothesis for the initiation of genetic recombination from recognition sites}
author = {Markham, P}
abstractNote = {Consideration of the initiation of genetic recombination from fixed sites recognised by an initiation complex, has provided more details of the envisaged mechanism and implications of a recent hypothesis. It has been shown that the hypothesis allows for more than one recombinogenic-event to result from a single binding of the recombination initiation complex to a recognition site in a DNA duplex. This capacity can explain data from fungal systems which are apparently inconsistent with the Meselson-Radding model of genetic recombination with respect to the positional relationship between tracts of hybrid DNA and sites of crossing-over. A mechanism for conversion, involving hybrid DNA formation, but without mismatch correction has also been proposed on the basis of this capacity. It is suggested that the hypothesis may apply generally to genetic recombination, in prokaryotes as well as eukaryotes.}
journal = {Biomed. Pharmacother.; (France)}
volume = {36:3}
journal type = {AC}
place = {France}
year = {1982}
month = {Jan}
}