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Effect of some radiosensitising drugs on human erythrocyte membrane - - spin label study

Journal Article:

Abstract

Electron spin resonance and spin label techniques have been employed to study the effects of local anaesthetic drugs, procaine and tetracaine, on human erythrocyte membrane. Both the drugs altered the protein and lipid arrangements in the membrane and these changes were reversible. Procaine had greater effect on the labels attached to proteins while tetracaine fluidized interior of lipid bilayer to a greater extent. The differential effects of these drugs on the protein and lipid labels have been interpreted in terms of their relative penetrability in the membrane. Present results have explained that radiation induced enhanced killing of cells in the presence of these drugs might be due to the alterations in membrane, particularly proteins both structural and enzymatic. In addition, these results indicate a possible relationship between drug-induced structural changes in membrane and their anaesthetic potency.
Authors:
Mishra, K P [1] 
  1. Bhabha Atomic Research Centre, Bombay (India). Biology and Agriculture Div.
Publication Date:
Feb 01, 1982
Product Type:
Journal Article
Reference Number:
AIX-14-731781; EDB-83-069860
Resource Relation:
Journal Name: Indian J. Biochem. Biophys.; (India); Journal Volume: 19:1; Other Information: 25 refs
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CELL MEMBRANES; RADIOSENSITIZERS; ERYTHROCYTES; PROCAINE; RADIOSENSITIVITY EFFECTS; BIOLOGICAL EFFECTS; CELL KILLING; ELECTRON SPIN RESONANCE; LABELLING; MAN; MORPHOLOGICAL CHANGES; ANESTHETICS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CELL CONSTITUENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DRUGS; MAGNETIC RESONANCE; MAMMALS; MATERIALS; MEMBRANES; PRIMATES; RESONANCE; VERTEBRATES; 560151* - Radiation Effects on Animals- Man
OSTI ID:
6429306
Country of Origin:
India
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IJBBB
Submitting Site:
HEDB
Size:
Pages: 21-26
Announcement Date:

Journal Article:

Citation Formats

Mishra, K P. Effect of some radiosensitising drugs on human erythrocyte membrane - - spin label study. India: N. p., 1982. Web.
Mishra, K P. Effect of some radiosensitising drugs on human erythrocyte membrane - - spin label study. India.
Mishra, K P. 1982. "Effect of some radiosensitising drugs on human erythrocyte membrane - - spin label study." India.
@misc{etde_6429306,
title = {Effect of some radiosensitising drugs on human erythrocyte membrane - - spin label study}
author = {Mishra, K P}
abstractNote = {Electron spin resonance and spin label techniques have been employed to study the effects of local anaesthetic drugs, procaine and tetracaine, on human erythrocyte membrane. Both the drugs altered the protein and lipid arrangements in the membrane and these changes were reversible. Procaine had greater effect on the labels attached to proteins while tetracaine fluidized interior of lipid bilayer to a greater extent. The differential effects of these drugs on the protein and lipid labels have been interpreted in terms of their relative penetrability in the membrane. Present results have explained that radiation induced enhanced killing of cells in the presence of these drugs might be due to the alterations in membrane, particularly proteins both structural and enzymatic. In addition, these results indicate a possible relationship between drug-induced structural changes in membrane and their anaesthetic potency.}
journal = {Indian J. Biochem. Biophys.; (India)}
volume = {19:1}
journal type = {AC}
place = {India}
year = {1982}
month = {Feb}
}