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Biotelemetric detection of the disappearance of subcutaneously injected /sup 125/I-NPH insulin

Journal Article:

Abstract

A biotelemetric method with Geiger-Mueller (GM) detectors fixed to the skin surface was used for continuous registration of the disappearance rate of subcutaneously injected /sup 125/I-NPH insulin. Methodological problems concerning counting geometry were investigated by comparing the disappearance of radioactivity, measured the GM- and NaI-detectors, respectively, and by scanning of the radioactive source. The size and position of the subcutaneous depot was unchanged throughout the study. Movement artifacts could be avoided. The coefficient of variation for distribution of ratios between count rates for GM- and NaI-detectors was 3.0% +/- 1.1 (SD) (range 0.9-4.0%) over periods of 24 h. It is concluded that the biotelemetry technique proved to be a clinically useful procedure for insulin absorption studies.
Publication Date:
Feb 01, 1982
Product Type:
Journal Article
Reference Number:
EDB-83-060420
Resource Relation:
Journal Name: Clin. Physiol.; (United Kingdom); Journal Volume: 2:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; INSULIN; BIOCHEMICAL REACTION KINETICS; METABOLISM; IODINE 125; TRACER TECHNIQUES; LABELLED COMPOUNDS; PATHOLOGY; PATIENTS; SUBCUTANEOUS INJECTION; BETA DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; HORMONES; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; NUCLEI; ODD-EVEN NUCLEI; PEPTIDE HORMONES; RADIOISOTOPES; REACTION KINETICS; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550201 - Biochemistry- Tracer Techniques; 551001 - Physiological Systems- Tracer Techniques
OSTI ID:
6427267
Research Organizations:
Department of Endocrinology E, Frederiksberg Hospital, Copenhagen, Denmark
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CLPHD
Submitting Site:
HEDB
Size:
Pages: 13-20
Announcement Date:
Dec 01, 1982

Journal Article:

Citation Formats

Kolendorf, K, and Bojsen, J. Biotelemetric detection of the disappearance of subcutaneously injected /sup 125/I-NPH insulin. United Kingdom: N. p., 1982. Web.
Kolendorf, K, & Bojsen, J. Biotelemetric detection of the disappearance of subcutaneously injected /sup 125/I-NPH insulin. United Kingdom.
Kolendorf, K, and Bojsen, J. 1982. "Biotelemetric detection of the disappearance of subcutaneously injected /sup 125/I-NPH insulin." United Kingdom.
@misc{etde_6427267,
title = {Biotelemetric detection of the disappearance of subcutaneously injected /sup 125/I-NPH insulin}
author = {Kolendorf, K, and Bojsen, J}
abstractNote = {A biotelemetric method with Geiger-Mueller (GM) detectors fixed to the skin surface was used for continuous registration of the disappearance rate of subcutaneously injected /sup 125/I-NPH insulin. Methodological problems concerning counting geometry were investigated by comparing the disappearance of radioactivity, measured the GM- and NaI-detectors, respectively, and by scanning of the radioactive source. The size and position of the subcutaneous depot was unchanged throughout the study. Movement artifacts could be avoided. The coefficient of variation for distribution of ratios between count rates for GM- and NaI-detectors was 3.0% +/- 1.1 (SD) (range 0.9-4.0%) over periods of 24 h. It is concluded that the biotelemetry technique proved to be a clinically useful procedure for insulin absorption studies.}
journal = {Clin. Physiol.; (United Kingdom)}
volume = {2:1}
journal type = {AC}
place = {United Kingdom}
year = {1982}
month = {Feb}
}