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Fibrin related antigens: assay development, clinical and kinetic studies

Thesis/Dissertation:

Abstract

This thesis describes an assay which is able to measure and to determine the proportions of fibrin- and fibrinogen-related antigens (FRA) present in clinical samples. No assay exists at present which is capable of distinguishing between fibrin and fibrinogen degradation products concurrently and in a clinical setting. The assay may be used as a tool with which to gain further insight to pathophysiology of disorders characterized by activation of the coagulation and fibrinolytic pathways. This study provides and analysis of the FRA profiles in patients with disorders characterised by possible enhanced fibrinolytic activity. Studies have been undertaken on patients with acute and chronic liver diseases, on patients with the various syndromes of coronary artery disease and on patients with insulin-dependent diabetes mellitus with and without evidence of microvascular disease. Certain observations made it evident that further studies were required in order to explain previously undocumented fibrinolytic abnormalities in certain patient groups. Data obtained from patients with liver disease provided information compatible with the activation of their fibrinolytic pathways. The initial scope of this study was then extended to further investigate the deranged haemostatic mechanisms in patients with severe liver diseases. Kinetic studies were performed which required the development of specific  More>>
Authors:
Publication Date:
Aug 01, 1987
Product Type:
Thesis/Dissertation
Reference Number:
AIX-20-022314; EDB-89-042203
Resource Relation:
Other Information: Thesis (Ph. D.)
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; FIBRIN; BLOOD CHEMISTRY; RADIOIMMUNOASSAY; FIBRINOGEN; FIBRINOLYSIS; DIAGNOSIS; ALBUMINS; ANTIGENS; BLOOD SERUM; CARCINOMAS; CORONARIES; DIABETES MELLITUS; DIMERS; EXPERIMENTAL DATA; HYDROLYSIS; IODINE 125; ISCHEMIA; ISOTOPE DILUTION; LABELLING; LIVER; MATHEMATICAL MODELS; MONOMERS; MYOCARDIAL INFARCTION; PATIENTS; THROMBIN; VASCULAR DISEASES; ARTERIES; BETA DECAY RADIOISOTOPES; BLOOD COAGULATION FACTORS; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CHEMICAL REACTIONS; COAGULANTS; DATA; DAYS LIVING RADIOISOTOPES; DECOMPOSITION; DIGESTIVE SYSTEM; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; ENDOCRINE DISEASES; ENZYMES; GLANDS; GLOBULINS; HEMATOLOGIC AGENTS; HEMOSTATICS; HYDROLASES; IMMUNOASSAY; IMMUNOLOGY; INFORMATION; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LYSIS; METABOLIC DISEASES; NEOPLASMS; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HYDROLASES; PROTEINS; PROTEOLYSIS; RADIOASSAY; RADIOIMMUNOLOGY; RADIOISOTOPES; SCLEROPROTEINS; SERINE PROTEINASES; SOLVOLYSIS; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6405906
Research Organizations:
Cape Town Univ. (South Africa)
Country of Origin:
South Africa
Language:
English
Availability:
the Registrar, University of Cape Town, University Private Bag, Rondebosch, 7700, South Africa.
Submitting Site:
INIS
Size:
Pages: 312
Announcement Date:

Thesis/Dissertation:

Citation Formats

Kruskal, J B. Fibrin related antigens: assay development, clinical and kinetic studies. South Africa: N. p., 1987. Web.
Kruskal, J B. Fibrin related antigens: assay development, clinical and kinetic studies. South Africa.
Kruskal, J B. 1987. "Fibrin related antigens: assay development, clinical and kinetic studies." South Africa.
@misc{etde_6405906,
title = {Fibrin related antigens: assay development, clinical and kinetic studies}
author = {Kruskal, J B}
abstractNote = {This thesis describes an assay which is able to measure and to determine the proportions of fibrin- and fibrinogen-related antigens (FRA) present in clinical samples. No assay exists at present which is capable of distinguishing between fibrin and fibrinogen degradation products concurrently and in a clinical setting. The assay may be used as a tool with which to gain further insight to pathophysiology of disorders characterized by activation of the coagulation and fibrinolytic pathways. This study provides and analysis of the FRA profiles in patients with disorders characterised by possible enhanced fibrinolytic activity. Studies have been undertaken on patients with acute and chronic liver diseases, on patients with the various syndromes of coronary artery disease and on patients with insulin-dependent diabetes mellitus with and without evidence of microvascular disease. Certain observations made it evident that further studies were required in order to explain previously undocumented fibrinolytic abnormalities in certain patient groups. Data obtained from patients with liver disease provided information compatible with the activation of their fibrinolytic pathways. The initial scope of this study was then extended to further investigate the deranged haemostatic mechanisms in patients with severe liver diseases. Kinetic studies were performed which required the development of specific technology to be able to measure certain previously undertermined parameters. Mathematical models describing the rates of fibrin formation and lysis were developed for human studies. Fibrin-derived D-dimer was radiolabelled and its validity as and intravenous tracer and maker of fibrin degradation established.}
place = {South Africa}
year = {1987}
month = {Aug}
}