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The measurement of the nigrostriatal dopaminergic function and glucose metabolism in patients with movement disorders

Journal Article:

Abstract

The nigrostriatal dopaminergic function and glucose metabolism were evaluated in 34 patients with various movement disorders by using positron emission tomography with [sup 18]F-Dopa and [sup 18]F-FDG respectively. The [sup 18]F-Dopa uptake in the striatum (the caudate head and the putamen) decreased in patients with Parkinson's disease but was relatively unaffected in the caudate. The cerebral glucose metabolism was normal in patients with Parkinson's disease. The [sup 18]F-Dopa uptake in the striatum also decreased in cases of atypical parkinsonism and in cases of progressive supranuclear palsy, but there was no difference in the uptake between the caudate and the putamen. The glucose metabolism decreased in the cerebral hemisphere including the striatum; this finding was also different from those of Parkinson's disease. A normal [sup 18]F-Dopa uptake in the striatum with a markedly decreased striatal glucose metabolism and a mildly decreased cortical glucose metabolism was observed in cases of Huntington's disease and Wilson's disease. The [sup 18]F-Dopa uptake in the striatum increased and the glucose metabolism was normal in cases of idiopathic dystonia. Various patterns of [sup 18]F-Dopa uptake and glucose metabolism were thus observed in the various movement disorders. These results suggest that the measurements of the [sup 18]F-Dopa uptake  More>>
Authors:
Otsuka, Makoto; Ichiya, Yuichi; Kuwabara, Yasuo; Sasaki, Masayuki; Fukumura, Toshimitsu; Masuda, Kouji; Shima, Fumio; Kato, Motohiro [1] 
  1. Kyushu Univ., Fukuoka (Japan). Faculty of Medicine
Publication Date:
Dec 01, 1992
Product Type:
Journal Article
Reference Number:
JPN-93-005279; EDB-93-085992
Resource Relation:
Journal Name: CT Kenkyu (Progress in Computerised Tomography); (Japan); Journal Volume: 14:6
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBRUM; POSITRON COMPUTED TOMOGRAPHY; FLUORINE 18; DOPAMINE; GLUCOSE; METABOLISM; NERVOUS SYSTEM DISEASES; UPTAKE; ALDEHYDES; AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; BRAIN; CARBOHYDRATES; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HEXOSES; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MONOSACCHARIDES; NANOSEC LIVING RADIOISOTOPES; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; RADIOISOTOPES; SACCHARIDES; SYMPATHOMIMETICS; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6387092
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0387-8015; CODEN: CTKEDI
Submitting Site:
JPN
Size:
Pages: 551-556
Announcement Date:

Journal Article:

Citation Formats

Otsuka, Makoto, Ichiya, Yuichi, Kuwabara, Yasuo, Sasaki, Masayuki, Fukumura, Toshimitsu, Masuda, Kouji, Shima, Fumio, and Kato, Motohiro. The measurement of the nigrostriatal dopaminergic function and glucose metabolism in patients with movement disorders. Japan: N. p., 1992. Web.
Otsuka, Makoto, Ichiya, Yuichi, Kuwabara, Yasuo, Sasaki, Masayuki, Fukumura, Toshimitsu, Masuda, Kouji, Shima, Fumio, & Kato, Motohiro. The measurement of the nigrostriatal dopaminergic function and glucose metabolism in patients with movement disorders. Japan.
Otsuka, Makoto, Ichiya, Yuichi, Kuwabara, Yasuo, Sasaki, Masayuki, Fukumura, Toshimitsu, Masuda, Kouji, Shima, Fumio, and Kato, Motohiro. 1992. "The measurement of the nigrostriatal dopaminergic function and glucose metabolism in patients with movement disorders." Japan.
@misc{etde_6387092,
title = {The measurement of the nigrostriatal dopaminergic function and glucose metabolism in patients with movement disorders}
author = {Otsuka, Makoto, Ichiya, Yuichi, Kuwabara, Yasuo, Sasaki, Masayuki, Fukumura, Toshimitsu, Masuda, Kouji, Shima, Fumio, and Kato, Motohiro}
abstractNote = {The nigrostriatal dopaminergic function and glucose metabolism were evaluated in 34 patients with various movement disorders by using positron emission tomography with [sup 18]F-Dopa and [sup 18]F-FDG respectively. The [sup 18]F-Dopa uptake in the striatum (the caudate head and the putamen) decreased in patients with Parkinson's disease but was relatively unaffected in the caudate. The cerebral glucose metabolism was normal in patients with Parkinson's disease. The [sup 18]F-Dopa uptake in the striatum also decreased in cases of atypical parkinsonism and in cases of progressive supranuclear palsy, but there was no difference in the uptake between the caudate and the putamen. The glucose metabolism decreased in the cerebral hemisphere including the striatum; this finding was also different from those of Parkinson's disease. A normal [sup 18]F-Dopa uptake in the striatum with a markedly decreased striatal glucose metabolism and a mildly decreased cortical glucose metabolism was observed in cases of Huntington's disease and Wilson's disease. The [sup 18]F-Dopa uptake in the striatum increased and the glucose metabolism was normal in cases of idiopathic dystonia. Various patterns of [sup 18]F-Dopa uptake and glucose metabolism were thus observed in the various movement disorders. These results suggest that the measurements of the [sup 18]F-Dopa uptake and the cerebral glucose metabolism would be useful for the evaluation of the striatal function in various movement disorders. (author).}
journal = {CT Kenkyu (Progress in Computerised Tomography); (Japan)}
volume = {14:6}
journal type = {AC}
place = {Japan}
year = {1992}
month = {Dec}
}