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Mutagenic activities of metal compounds in bacteria

Journal Article:

Abstract

Environmental contaminations by certain metal compounds are bringing about serious problems to human health, including genetic hazards. It has been reported that some compounds of iron, manganese and mercury induce point mutations in microorganisms. Also it has been observed that those of aluminum, antimony, arsenic, cadmium, lead and tellurium cause chromosome aberrations in plants, insects and cultured human cells. The mechanism of mutation induction by these metals remains, however, still obscure. For screening of chemical mutagens, Kada et al, recently developed a simple and efficient method named rec-assay by observing differential growth sensitivities to drugs in wild and recombination-deficient strains of Bacillus subtilis. When a chemical is more inhibitory for Rec/sup -/ than for Rec/sup +/ cells, it is reasonable to suspect mutagenicity based on its DNA-damaging capacity. In the present report, 56 metal compounds were tested by the rec-assay. Compounds showing positive results in the assay such as potassium dichromate (K/sub 2/Cr/sub 2/O/sub 7/), ammonium molybdate ((NH/sub 4/)/sub 6/Mo/sub 7/O/sub 24/) and sodium arsenite (NaAsO/sub 2/) were then examined as to their capacities to induce reversions in E. coli Trp/sup -/ strains possessing different DNA repair pathways. 11 references, 3 tables.
Authors:
Publication Date:
Jan 01, 1975
Product Type:
Journal Article
Reference Number:
EDB-86-055141
Resource Relation:
Journal Name: Mutat. Res.; (Netherlands); Journal Volume: 31:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ALUMINIUM; BIOLOGICAL EFFECTS; ANTIMONY; ARSENIC; BACILLUS SUBTILIS; MUTAGENESIS; CADMIUM; ESCHERICHIA COLI; IRON; LEAD; MANGANESE; MERCURY; TELLURIUM; AMMONIUM COMPOUNDS; EXPERIMENTAL DATA; MUTAGENS; POTASSIUM COMPOUNDS; SCREENING; SODIUM COMPOUNDS; ALKALI METAL COMPOUNDS; BACILLUS; BACTERIA; DATA; ELEMENTS; INFORMATION; METALS; MICROORGANISMS; NUMERICAL DATA; SEMIMETALS; TRANSITION ELEMENTS; 560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)
OSTI ID:
6385060
Research Organizations:
Doshisha Univ., Kyoto, Japan
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: MUREA
Submitting Site:
JMT
Size:
Pages: 185-189
Announcement Date:

Journal Article:

Citation Formats

Nishioka, H. Mutagenic activities of metal compounds in bacteria. Netherlands: N. p., 1975. Web.
Nishioka, H. Mutagenic activities of metal compounds in bacteria. Netherlands.
Nishioka, H. 1975. "Mutagenic activities of metal compounds in bacteria." Netherlands.
@misc{etde_6385060,
title = {Mutagenic activities of metal compounds in bacteria}
author = {Nishioka, H}
abstractNote = {Environmental contaminations by certain metal compounds are bringing about serious problems to human health, including genetic hazards. It has been reported that some compounds of iron, manganese and mercury induce point mutations in microorganisms. Also it has been observed that those of aluminum, antimony, arsenic, cadmium, lead and tellurium cause chromosome aberrations in plants, insects and cultured human cells. The mechanism of mutation induction by these metals remains, however, still obscure. For screening of chemical mutagens, Kada et al, recently developed a simple and efficient method named rec-assay by observing differential growth sensitivities to drugs in wild and recombination-deficient strains of Bacillus subtilis. When a chemical is more inhibitory for Rec/sup -/ than for Rec/sup +/ cells, it is reasonable to suspect mutagenicity based on its DNA-damaging capacity. In the present report, 56 metal compounds were tested by the rec-assay. Compounds showing positive results in the assay such as potassium dichromate (K/sub 2/Cr/sub 2/O/sub 7/), ammonium molybdate ((NH/sub 4/)/sub 6/Mo/sub 7/O/sub 24/) and sodium arsenite (NaAsO/sub 2/) were then examined as to their capacities to induce reversions in E. coli Trp/sup -/ strains possessing different DNA repair pathways. 11 references, 3 tables.}
journal = {Mutat. Res.; (Netherlands)}
volume = {31:3}
journal type = {AC}
place = {Netherlands}
year = {1975}
month = {Jan}
}