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Biochemical evidence for overlapping neocortical and allocortical glutamate projections to the nucleus accumbens and rostral caudatoputamen in the rat brain

Journal Article:

Abstract

The high affinity uptake of L-glutamate has been used to investigate the origin and distribution of putative glutamate fibers in restricted parts of the rostral caudatoputamen and the nucleus accumbens of the rat brain. Ablation of the frontal cortex reduced the glutamate uptake heavily (-77%) in the dorsal part of the ipsilateral caudatoputamen, but also led to significant decreases in the ventral parts of the ipsilateral caudatoputamen (-62% and -53%) in the ipsilateral nucleus accumbens (-25% and -18%) and in the contralateral dorsal part of the caudatoputamen (-21%). Lesion of the caudal neocortex reduced the glutamate uptake in the dorsal part of the ipsilateral caudatoputamen only (-23%). Lesions of the fimbria/fornix reduced the glutamate uptake in both parts of the ipsilateral nucleus accumbens (-46% and -34%) and by approximately 20% in the whole dorsoventral extent of the anterior caudatoputamen. The results indicate that the frontal neocortex distributes fibers which may use glutamate as neurotransmitter both to the whole ipsilateral caudatoputamen and to the nucleus accumbens, and also to the dorsal parts of the contralateral caudatoputamen. The caudal neocortex probably sends such fibers to the dorsal ipsilateral caudatoputamen and the caudal allocortex sends such fibers through the fimbria/fornix to the nucleus  More>>
Authors:
Publication Date:
Jan 01, 1981
Product Type:
Journal Article
Reference Number:
EDB-83-088333
Resource Relation:
Journal Name: Neuroscience; (United Kingdom); Journal Volume: 6:3
Subject:
59 BASIC BIOLOGICAL SCIENCES; BRAIN; MORPHOLOGY; BIOCHEMISTRY; GLUTAMIC ACID; NERVE CELLS; RATS; TRACER TECHNIQUES; TRITIUM COMPOUNDS; AMINO ACIDS; ANIMAL CELLS; ANIMALS; BODY; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; CHEMISTRY; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; NERVOUS SYSTEM; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RODENTS; SOMATIC CELLS; VERTEBRATES; 550801* - Morphology- Tracer Techniques; 550201 - Biochemistry- Tracer Techniques
OSTI ID:
6381412
Research Organizations:
Norwegian Defence Research Establishment, Kjeller, Norway
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NRSCD
Submitting Site:
HEDB
Size:
Pages: 399-405
Announcement Date:

Journal Article:

Citation Formats

Walaas, I. Biochemical evidence for overlapping neocortical and allocortical glutamate projections to the nucleus accumbens and rostral caudatoputamen in the rat brain. United Kingdom: N. p., 1981. Web.
Walaas, I. Biochemical evidence for overlapping neocortical and allocortical glutamate projections to the nucleus accumbens and rostral caudatoputamen in the rat brain. United Kingdom.
Walaas, I. 1981. "Biochemical evidence for overlapping neocortical and allocortical glutamate projections to the nucleus accumbens and rostral caudatoputamen in the rat brain." United Kingdom.
@misc{etde_6381412,
title = {Biochemical evidence for overlapping neocortical and allocortical glutamate projections to the nucleus accumbens and rostral caudatoputamen in the rat brain}
author = {Walaas, I}
abstractNote = {The high affinity uptake of L-glutamate has been used to investigate the origin and distribution of putative glutamate fibers in restricted parts of the rostral caudatoputamen and the nucleus accumbens of the rat brain. Ablation of the frontal cortex reduced the glutamate uptake heavily (-77%) in the dorsal part of the ipsilateral caudatoputamen, but also led to significant decreases in the ventral parts of the ipsilateral caudatoputamen (-62% and -53%) in the ipsilateral nucleus accumbens (-25% and -18%) and in the contralateral dorsal part of the caudatoputamen (-21%). Lesion of the caudal neocortex reduced the glutamate uptake in the dorsal part of the ipsilateral caudatoputamen only (-23%). Lesions of the fimbria/fornix reduced the glutamate uptake in both parts of the ipsilateral nucleus accumbens (-46% and -34%) and by approximately 20% in the whole dorsoventral extent of the anterior caudatoputamen. The results indicate that the frontal neocortex distributes fibers which may use glutamate as neurotransmitter both to the whole ipsilateral caudatoputamen and to the nucleus accumbens, and also to the dorsal parts of the contralateral caudatoputamen. The caudal neocortex probably sends such fibers to the dorsal ipsilateral caudatoputamen and the caudal allocortex sends such fibers through the fimbria/fornix to the nucleus accumbens and the ventral part of the ipsilateral caudatoputamen. The results thus corroborate previous suggestions of close similarities between the nucleus accumbens and the ventral caudatoputamen.}
journal = {Neuroscience; (United Kingdom)}
volume = {6:3}
journal type = {AC}
place = {United Kingdom}
year = {1981}
month = {Jan}
}