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Production of lung cancer in mice by inhalation exposure to influenza virus and aerosols of hydrocarbons

Journal Article:

Abstract

1800 C57 (tumor-resistant) mice were exposed in chambers to washed air, repeated influenza virus, artificial smog with 1 to 2 ppM oxidant (ozonized gasoline), or a combination of smog and influenza. Squamous lesions were produced in flu (11) and flu plus smog (33) groups but not in control or smog only groups. The flu only lesions did not show keratinization, pleomorphism and atypical mitoses, or vascular or lymphatic invasion as did lesions in flu + smog. Use of proliferative stimulus plus carcinogenic hydrocarbon resulted in keratinizing metaplasia and squamous cell carcinoma not previously produced by other inhalation techniques.
Publication Date:
Jan 01, 1963
Product Type:
Journal Article
Reference Number:
EDB-79-101552
Resource Relation:
Journal Name: Prog. Exp. Tumor Res.; (Switzerland); Journal Volume: 3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HYDROCARBONS; HEALTH HAZARDS; INFLUENZA; AEROSOLS; CARCINOGENS; CARCINOMAS; GASOLINE; INHALATION; LUNGS; MICE; MORPHOLOGICAL CHANGES; OXIDIZERS; OZONE; PATHOLOGICAL CHANGES; SMOG; SYNERGISM; VIRUSES; ANIMALS; BODY; COLLOIDS; DISEASES; DISPERSIONS; FUELS; HAZARDS; INFECTIOUS DISEASES; INTAKE; MAMMALS; MICROORGANISMS; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; PARASITES; PETROLEUM PRODUCTS; RESPIRATORY SYSTEM; RODENTS; SOLS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
6380762
Country of Origin:
Switzerland
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PEXTA
Submitting Site:
TIC
Size:
Pages: 186-215
Announcement Date:

Journal Article:

Citation Formats

Kotin, P, and Wiseley, D V. Production of lung cancer in mice by inhalation exposure to influenza virus and aerosols of hydrocarbons. Switzerland: N. p., 1963. Web.
Kotin, P, & Wiseley, D V. Production of lung cancer in mice by inhalation exposure to influenza virus and aerosols of hydrocarbons. Switzerland.
Kotin, P, and Wiseley, D V. 1963. "Production of lung cancer in mice by inhalation exposure to influenza virus and aerosols of hydrocarbons." Switzerland.
@misc{etde_6380762,
title = {Production of lung cancer in mice by inhalation exposure to influenza virus and aerosols of hydrocarbons}
author = {Kotin, P, and Wiseley, D V}
abstractNote = {1800 C57 (tumor-resistant) mice were exposed in chambers to washed air, repeated influenza virus, artificial smog with 1 to 2 ppM oxidant (ozonized gasoline), or a combination of smog and influenza. Squamous lesions were produced in flu (11) and flu plus smog (33) groups but not in control or smog only groups. The flu only lesions did not show keratinization, pleomorphism and atypical mitoses, or vascular or lymphatic invasion as did lesions in flu + smog. Use of proliferative stimulus plus carcinogenic hydrocarbon resulted in keratinizing metaplasia and squamous cell carcinoma not previously produced by other inhalation techniques.}
journal = {Prog. Exp. Tumor Res.; (Switzerland)}
volume = {3}
journal type = {AC}
place = {Switzerland}
year = {1963}
month = {Jan}
}