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Quantitative cerebral blood flow assessment in senile dementia of Alzheimer type and multi-infarct dementia using sup 123 I-IMP SPECT

Journal Article:

Abstract

In order to compare senile dementia of Alzheimer type (SDAT) with multi-infarct dementia (MID) from the standpoint of cerebral blood flow, a study was carried out by using single photon emission CT (SPECT) with N-isopropyl-p-({sup 123}I) iodoamphetamine on 14 healthy aged subjects, 12 patients with SDAT, 8 patients with MID and 7 patients with multiple infarction (MI). The diagnosis of SDAT, MID and MI was based on a clinical history, X-ray CT findings and Hachinski's ischemic score. Venous blood sampling method of Matsuda et al. was used as quantitative cerebral blood flow measurements. The mean cerebral blood flow (mCBF) values in controls was 52.1{plus minus}5.5 ml/100 g/min, while the corresponding values in SDAT, MI and MID were 36.9{plus minus}5.0, 41.0{plus minus}6.2, and 37.7{plus minus}4.3 ml/100 g/min. The regional cerebral blood flow (rCBF) was decreased mainly at bilateral frontal lobes in MID and at temporal and parietal lobes in SDAT. Verbal intelligence score (Hasegawa's dementia score) correlated with rCBF at frontal lobes in MID. These findings suggest that quantitative rCBF measurement by {sup 123}I-IMP SPECT is useful to differentiate MID from SDAT. (author).
Publication Date:
Jun 01, 1990
Product Type:
Journal Article
Reference Number:
JPN-90-010210; EDB-90-174229
Resource Relation:
Journal Name: Nippon Gazo Igaku Zasshi (Japanese Journal of Medical Imaging); (Japan); Journal Volume: 9:2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; IODINE 123; BENZEDRINE; BLOOD FLOW; ELDERLY PEOPLE; MENTAL DISORDERS; VASCULAR DISEASES; AGE GROUPS; AGED ADULTS; AMINES; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HOURS LIVING RADIOISOTOPES; HUMAN POPULATIONS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MINORITY GROUPS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; POPULATIONS; RADIOISOTOPES; SYMPATHOMIMETICS; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6368645
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0289-0925; CODEN: NGIZE
Submitting Site:
JPN
Size:
Pages: 97-106
Announcement Date:

Journal Article:

Citation Formats

Arai, Hisayuki, Hanyu, Haruo, Kobayashi, Yasutaka, Uno, Masanobu, Hatano, Nobuyoshi, Shin, Kouichi, Katsunuma, Hideyo, Suzuki, Takanari, and Murayama, Hiroyasu. Quantitative cerebral blood flow assessment in senile dementia of Alzheimer type and multi-infarct dementia using sup 123 I-IMP SPECT. Japan: N. p., 1990. Web.
Arai, Hisayuki, Hanyu, Haruo, Kobayashi, Yasutaka, Uno, Masanobu, Hatano, Nobuyoshi, Shin, Kouichi, Katsunuma, Hideyo, Suzuki, Takanari, & Murayama, Hiroyasu. Quantitative cerebral blood flow assessment in senile dementia of Alzheimer type and multi-infarct dementia using sup 123 I-IMP SPECT. Japan.
Arai, Hisayuki, Hanyu, Haruo, Kobayashi, Yasutaka, Uno, Masanobu, Hatano, Nobuyoshi, Shin, Kouichi, Katsunuma, Hideyo, Suzuki, Takanari, and Murayama, Hiroyasu. 1990. "Quantitative cerebral blood flow assessment in senile dementia of Alzheimer type and multi-infarct dementia using sup 123 I-IMP SPECT." Japan.
@misc{etde_6368645,
title = {Quantitative cerebral blood flow assessment in senile dementia of Alzheimer type and multi-infarct dementia using sup 123 I-IMP SPECT}
author = {Arai, Hisayuki, Hanyu, Haruo, Kobayashi, Yasutaka, Uno, Masanobu, Hatano, Nobuyoshi, Shin, Kouichi, Katsunuma, Hideyo, Suzuki, Takanari, and Murayama, Hiroyasu}
abstractNote = {In order to compare senile dementia of Alzheimer type (SDAT) with multi-infarct dementia (MID) from the standpoint of cerebral blood flow, a study was carried out by using single photon emission CT (SPECT) with N-isopropyl-p-({sup 123}I) iodoamphetamine on 14 healthy aged subjects, 12 patients with SDAT, 8 patients with MID and 7 patients with multiple infarction (MI). The diagnosis of SDAT, MID and MI was based on a clinical history, X-ray CT findings and Hachinski's ischemic score. Venous blood sampling method of Matsuda et al. was used as quantitative cerebral blood flow measurements. The mean cerebral blood flow (mCBF) values in controls was 52.1{plus minus}5.5 ml/100 g/min, while the corresponding values in SDAT, MI and MID were 36.9{plus minus}5.0, 41.0{plus minus}6.2, and 37.7{plus minus}4.3 ml/100 g/min. The regional cerebral blood flow (rCBF) was decreased mainly at bilateral frontal lobes in MID and at temporal and parietal lobes in SDAT. Verbal intelligence score (Hasegawa's dementia score) correlated with rCBF at frontal lobes in MID. These findings suggest that quantitative rCBF measurement by {sup 123}I-IMP SPECT is useful to differentiate MID from SDAT. (author).}
journal = {Nippon Gazo Igaku Zasshi (Japanese Journal of Medical Imaging); (Japan)}
volume = {9:2}
journal type = {AC}
place = {Japan}
year = {1990}
month = {Jun}
}