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Glucose consumption and rate constants for sup 18 F-fluorodeoxyglucose in human gliomas

Journal Article:

Abstract

To investigate the value of direct measurement of the rate constants by performing {sup 18}F-labeled fluorodeoxyglucose (FDG) studies of glucose consumption in human gliomas in vivo, a kinetic method with 3- and 4-parameter rate constant models for FDG uptake was used to analyze data from dynamic scans obtained by positron emission tomography after injection of FDG into 14 patients with glioma. The results were compared with those obtained by the autoradiographic method using 3- and 4-parameter rate constant models. There were no significant differences in the glucose consumption calculated by the four different methods both in the gliomas and in the contralateral intact cortex. It was found that the rate constant k4 could be neglected in calculation of glucose consumption in gliomas as well as in the contralateral intact cortex. The rate constant k3, an index of hexokinase function, was higher in malignant gliomas than in benign gliomas and was close to that in the contralateral cortex. This study indicates that the 3-parameter autoradiographic method, which is the most common one used in clinical practice, is reliable for the calculation of glucose consumption in human gliomas. Furthermore, direct measurement of the regional rate constants for FDG by the kinetic method  More>>
Publication Date:
Jun 01, 1990
Product Type:
Journal Article
Reference Number:
JPN-90-010238; EDB-90-174236
Resource Relation:
Journal Name: Neurologia Medico-Chirurgica; (Japan); Journal Volume: 30:6
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; POSITRON COMPUTED TOMOGRAPHY; FLUORINE 18; AUTORADIOGRAPHY; DYNAMIC FUNCTION STUDIES; FLUORODEOXYGLUCOSE; GLIOMAS; GLUCOSE; ALDEHYDES; ANTIMETABOLITES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HEXOSES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MONOSACCHARIDES; NEOPLASMS; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; SACCHARIDES; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6368567
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0387-2572; CODEN: NMCHB
Submitting Site:
JPN
Size:
Pages: 377-381
Announcement Date:

Journal Article:

Citation Formats

Ishikawa, Masatsune, Kikuchi, Haruhiko, Nagata, Izumi, Yamagata, Sen, Taki, Waro, Yonekura, Yoshiharu, Nishizawa, Sadahiko, Iwasaki, Yasushi, and Mukai, Takao. Glucose consumption and rate constants for sup 18 F-fluorodeoxyglucose in human gliomas. Japan: N. p., 1990. Web.
Ishikawa, Masatsune, Kikuchi, Haruhiko, Nagata, Izumi, Yamagata, Sen, Taki, Waro, Yonekura, Yoshiharu, Nishizawa, Sadahiko, Iwasaki, Yasushi, & Mukai, Takao. Glucose consumption and rate constants for sup 18 F-fluorodeoxyglucose in human gliomas. Japan.
Ishikawa, Masatsune, Kikuchi, Haruhiko, Nagata, Izumi, Yamagata, Sen, Taki, Waro, Yonekura, Yoshiharu, Nishizawa, Sadahiko, Iwasaki, Yasushi, and Mukai, Takao. 1990. "Glucose consumption and rate constants for sup 18 F-fluorodeoxyglucose in human gliomas." Japan.
@misc{etde_6368567,
title = {Glucose consumption and rate constants for sup 18 F-fluorodeoxyglucose in human gliomas}
author = {Ishikawa, Masatsune, Kikuchi, Haruhiko, Nagata, Izumi, Yamagata, Sen, Taki, Waro, Yonekura, Yoshiharu, Nishizawa, Sadahiko, Iwasaki, Yasushi, and Mukai, Takao}
abstractNote = {To investigate the value of direct measurement of the rate constants by performing {sup 18}F-labeled fluorodeoxyglucose (FDG) studies of glucose consumption in human gliomas in vivo, a kinetic method with 3- and 4-parameter rate constant models for FDG uptake was used to analyze data from dynamic scans obtained by positron emission tomography after injection of FDG into 14 patients with glioma. The results were compared with those obtained by the autoradiographic method using 3- and 4-parameter rate constant models. There were no significant differences in the glucose consumption calculated by the four different methods both in the gliomas and in the contralateral intact cortex. It was found that the rate constant k4 could be neglected in calculation of glucose consumption in gliomas as well as in the contralateral intact cortex. The rate constant k3, an index of hexokinase function, was higher in malignant gliomas than in benign gliomas and was close to that in the contralateral cortex. This study indicates that the 3-parameter autoradiographic method, which is the most common one used in clinical practice, is reliable for the calculation of glucose consumption in human gliomas. Furthermore, direct measurement of the regional rate constants for FDG by the kinetic method was found to be useful for evaluation of the biochemical and physiological characteristics of human gliomas in vivo. (author).}
journal = {Neurologia Medico-Chirurgica; (Japan)}
volume = {30:6}
journal type = {AC}
place = {Japan}
year = {1990}
month = {Jun}
}