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Association of myocardial cell necrosis with experimental cardiac hypertrophy

Abstract

Cardiac hypertrophy was induced in rabbits by injecting thyroxime or isoprenaline, or by surgically constricting the abdominal aorta. An increase in heart weight was associated with a change in the ratios of bound to free forms of five lysosomal enzymes, a change in serum creatine phosphokinase and lactate dehydrogenase, and a change in the morphology of the myocardial cells. Isoprenaline treatment for 5 days induced a maximal change in heart weight, in the ratio of lysosomal enzymes, and in the serum enzymes. Thyroxine treatment was required for 15 days before maximal changes in heart weight, ratio, and serum enzymes were observed. In contrast, coarctation of the aorta caused a progressive change in heart weight, in the ratio of lysosomal enzymes, and in serum enzymes. These results suggest that necrosis of the myocardial cells does indeed accompany cardiac hypertrophy. It was further observed that autophagosomes, degenerating mitochondria in the myocardial cells during the induction of cardiac hypertrophy, and myofibril lysis were found, all of which confirms the suggestion of myocardial cell necrosis in the experimentally enlarged heart.
Publication Date:
Jan 01, 1979
Product Type:
Journal Article
Reference Number:
ERA-06-022658; EDB-81-076554
Resource Relation:
Journal Name: J. Pathol.; (United Kingdom); Journal Volume: 128
Subject:
59 BASIC BIOLOGICAL SCIENCES; MYOCARDIUM; HYPERTROPHY; NECROSIS; ANIMAL CELLS; BIOCHEMICAL REACTION KINETICS; CATALYSIS; LACTATE DEHYDROGENASE; METABOLISM; MORPHOLOGY; PHOSPHOTRANSFERASES; RABBITS; ANIMALS; BODY; CARDIOVASCULAR SYSTEM; ENZYMES; HEART; HEMIACETAL DEHYDROGENASES; KINETICS; MAMMALS; MUSCLES; ORGANS; OXIDOREDUCTASES; PATHOLOGICAL CHANGES; PHOSPHORUS-GROUP TRANSFERASES; REACTION KINETICS; TRANSFERASES; VERTEBRATES; 550900* - Pathology; 550800 - Morphology; 550200 - Biochemistry
OSTI ID:
6355583
Research Organizations:
Oak Ridge National Lab., TN
Country of Origin:
United Kingdom
Language:
English
Contract Number:
W-7405-ENG-26
Other Identifying Numbers:
Journal ID: CODEN: JPTLA
Submitting Site:
ORNL
Size:
Pages: 193-202
Announcement Date:
Jun 01, 1981

Citation Formats

Revis, N W, and Cameron, A J.V. Association of myocardial cell necrosis with experimental cardiac hypertrophy. United Kingdom: N. p., 1979. Web. doi:10.1002/path.1711280405.
Revis, N W, & Cameron, A J.V. Association of myocardial cell necrosis with experimental cardiac hypertrophy. United Kingdom. doi:10.1002/path.1711280405.
Revis, N W, and Cameron, A J.V. 1979. "Association of myocardial cell necrosis with experimental cardiac hypertrophy." United Kingdom. doi:10.1002/path.1711280405. https://www.osti.gov/servlets/purl/10.1002/path.1711280405.
@misc{etde_6355583,
title = {Association of myocardial cell necrosis with experimental cardiac hypertrophy}
author = {Revis, N W, and Cameron, A J.V.}
abstractNote = {Cardiac hypertrophy was induced in rabbits by injecting thyroxime or isoprenaline, or by surgically constricting the abdominal aorta. An increase in heart weight was associated with a change in the ratios of bound to free forms of five lysosomal enzymes, a change in serum creatine phosphokinase and lactate dehydrogenase, and a change in the morphology of the myocardial cells. Isoprenaline treatment for 5 days induced a maximal change in heart weight, in the ratio of lysosomal enzymes, and in the serum enzymes. Thyroxine treatment was required for 15 days before maximal changes in heart weight, ratio, and serum enzymes were observed. In contrast, coarctation of the aorta caused a progressive change in heart weight, in the ratio of lysosomal enzymes, and in serum enzymes. These results suggest that necrosis of the myocardial cells does indeed accompany cardiac hypertrophy. It was further observed that autophagosomes, degenerating mitochondria in the myocardial cells during the induction of cardiac hypertrophy, and myofibril lysis were found, all of which confirms the suggestion of myocardial cell necrosis in the experimentally enlarged heart.}
doi = {10.1002/path.1711280405}
journal = {J. Pathol.; (United Kingdom)}
volume = {128}
journal type = {AC}
place = {United Kingdom}
year = {1979}
month = {Jan}
}