You need JavaScript to view this

Role of free radicals in radiation chemical aging

Abstract

Ionizing radiation initiates chemical changes in DNA, phospholipid membranes and other critical cell targets, that, if allowed to accumulate unrepaired, may lead to aging and other chronic effects. The chemical effects are free radical mediated, the principal damaging species being radical OH and to a lesser extent O2-anion radical and the molecular product H/sub 2/O/sub 2/. Many compounds can act in combination with ionizing radiation, to amplify the potential oxidative stress. Chemicals, ultra-violet light, lipid peroxides and their breakdown products may increase the extent of acute and chronic radiobiological effects.
Authors:
Publication Date:
Jan 01, 1986
Product Type:
Journal Article
Reference Number:
AIX-20-022142; EDB-89-042654
Resource Relation:
Journal Name: Prog. React. Kinet.; (United Kingdom); Journal Volume: 14:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; CHEMICAL RADIATION EFFECTS; LIFE SPAN; RADICALS; BIOLOGICAL RADIATION EFFECTS; CELL CULTURES; EXTERNAL IRRADIATION; HYDROGEN PEROXIDE; HYDROXYL RADICALS; IONIZING RADIATIONS; LIFE CYCLE; RADIOBIOLOGY; RADIOLYSIS; BIOLOGICAL EFFECTS; BIOLOGY; CHEMICAL REACTIONS; CHEMISTRY; DECOMPOSITION; HYDROGEN COMPOUNDS; IRRADIATION; OXYGEN COMPOUNDS; PEROXIDES; RADIATION CHEMISTRY; RADIATION EFFECTS; RADIATIONS; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture; 400600 - Radiation Chemistry
OSTI ID:
6350969
Research Organizations:
Atomic Energy of Canada Ltd., Pinawa, Manitoba. Whiteshell Nuclear Research Establishment
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PRKNA
Submitting Site:
INIS
Size:
Pages: 249-265
Announcement Date:
May 01, 1986

Citation Formats

Greenstock, C L. Role of free radicals in radiation chemical aging. United Kingdom: N. p., 1986. Web.
Greenstock, C L. Role of free radicals in radiation chemical aging. United Kingdom.
Greenstock, C L. 1986. "Role of free radicals in radiation chemical aging." United Kingdom.
@misc{etde_6350969,
title = {Role of free radicals in radiation chemical aging}
author = {Greenstock, C L}
abstractNote = {Ionizing radiation initiates chemical changes in DNA, phospholipid membranes and other critical cell targets, that, if allowed to accumulate unrepaired, may lead to aging and other chronic effects. The chemical effects are free radical mediated, the principal damaging species being radical OH and to a lesser extent O2-anion radical and the molecular product H/sub 2/O/sub 2/. Many compounds can act in combination with ionizing radiation, to amplify the potential oxidative stress. Chemicals, ultra-violet light, lipid peroxides and their breakdown products may increase the extent of acute and chronic radiobiological effects.}
journal = []
volume = {14:4}
journal type = {AC}
place = {United Kingdom}
year = {1986}
month = {Jan}
}