Abstract
A method for carrier-free labelling of n-butanol with the positron emitting radionuclide carbon-11 (half-life 20.4 min) is described. Labelling was achieved by carboxylation of n-propyl magnesium chloride with /sup 11/C-labelled carbon dioxide and the subsequent reduction of the resulting free (1-/sup 11/C)-butyric acid with LiAlH/sub 4/ after hydrolysis of the Grignard complex. The procedure permits /sup 11/C-labelled butanol to be prepared in high activity and high radiochemical purity for in vivo biological studies only 25 min after the start of carboxylation of the Grignard compound. Gas chromatography and HPLC were used to assess the purity of the product. To maintain carrier-free conditions, atmospheric carbon dioxide was rigorously excluded from all reagents and every parts of the apparatus.
Oberdorfer, F;
Helus, F;
Maier-Borst, W;
[1]
Silvester, D J
[2]
- Deutsches Krebsforschungszentrum, Heidelberg (Germany, F.R.)
- Hammersmith Hospital, London (UK). M.R.C. Cyclotron Unit
Citation Formats
Oberdorfer, F, Helus, F, Maier-Borst, W, and Silvester, D J.
Synthesis of (1-/sup 11/C)-butanol.
Switzerland: N. p.,
1982.
Web.
Oberdorfer, F, Helus, F, Maier-Borst, W, & Silvester, D J.
Synthesis of (1-/sup 11/C)-butanol.
Switzerland.
Oberdorfer, F, Helus, F, Maier-Borst, W, and Silvester, D J.
1982.
"Synthesis of (1-/sup 11/C)-butanol."
Switzerland.
@misc{etde_6346950,
title = {Synthesis of (1-/sup 11/C)-butanol}
author = {Oberdorfer, F, Helus, F, Maier-Borst, W, and Silvester, D J}
abstractNote = {A method for carrier-free labelling of n-butanol with the positron emitting radionuclide carbon-11 (half-life 20.4 min) is described. Labelling was achieved by carboxylation of n-propyl magnesium chloride with /sup 11/C-labelled carbon dioxide and the subsequent reduction of the resulting free (1-/sup 11/C)-butyric acid with LiAlH/sub 4/ after hydrolysis of the Grignard complex. The procedure permits /sup 11/C-labelled butanol to be prepared in high activity and high radiochemical purity for in vivo biological studies only 25 min after the start of carboxylation of the Grignard compound. Gas chromatography and HPLC were used to assess the purity of the product. To maintain carrier-free conditions, atmospheric carbon dioxide was rigorously excluded from all reagents and every parts of the apparatus.}
journal = []
volume = {53:4}
journal type = {AC}
place = {Switzerland}
year = {1982}
month = {Sep}
}
title = {Synthesis of (1-/sup 11/C)-butanol}
author = {Oberdorfer, F, Helus, F, Maier-Borst, W, and Silvester, D J}
abstractNote = {A method for carrier-free labelling of n-butanol with the positron emitting radionuclide carbon-11 (half-life 20.4 min) is described. Labelling was achieved by carboxylation of n-propyl magnesium chloride with /sup 11/C-labelled carbon dioxide and the subsequent reduction of the resulting free (1-/sup 11/C)-butyric acid with LiAlH/sub 4/ after hydrolysis of the Grignard complex. The procedure permits /sup 11/C-labelled butanol to be prepared in high activity and high radiochemical purity for in vivo biological studies only 25 min after the start of carboxylation of the Grignard compound. Gas chromatography and HPLC were used to assess the purity of the product. To maintain carrier-free conditions, atmospheric carbon dioxide was rigorously excluded from all reagents and every parts of the apparatus.}
journal = []
volume = {53:4}
journal type = {AC}
place = {Switzerland}
year = {1982}
month = {Sep}
}