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Voltammetric studies on composition and stabilities of complexes of tetracycline and oxytetracycline with some metal ions in aqueous medium. Voltammetrische Untersuchungen zur Zusammensetzung und Stabilitaet von Komplexen von Tetracyclin und Oxytetracyclin mit einigen Metallionen in waessrigem Medium

Journal Article:

Abstract

The composition and stability of complexes of tetracycline and oxytetracycline with Cu(II), Cd(II), Pb(II) and UO[sub 2](II) have been studied polarographically (direct current and differential pulse polarographic techniques) at 25[+-]0.1 deg C. Differential pulse polarographic studies have been particularly helpful in deciding the nature of metal-drug interactions at low concentrations. The reduction of Cu(II)-tetracycline has been found to be irreversible and diffusion controlled with the presence of an adsorption component. In the system uranyl(II)-tetracycline the complex formed has a stoichiometry of 1:1 and log K[sub ox] = 4.04 which is very close to that obtained by potentiometric measurements. The peak half width W[sub 1/2] of the Pb(II)-OTC system is 60-70 mV indicating that the process is reversible and two electrons are consumed. The log [beta]' is 10.30 in 0.1 mol dm[sup -3] NaClO[sub 4]. In the Cu(II)-OTC system two complexes were formed with log [beta][sub 1]' = 8.50 and log [beta][sub 2]' = 14.10. Cyclic voltammograms were recorded using a hanging dropping mercury electrode for the systems Cu(II), Cd(II), Pb(II) and UO[sub 2](II)-OTC to examine the irregularities in both peak potentials and peak currents during the polarographic investigations. (authors).
Authors:
Ghandour, M A; Azab, H A; Hassan, A; Ali, A M [1] 
  1. Dept. of Chemistry, Faculty of Science, Assiut Univ., Assiut (Egypt)
Publication Date:
Jan 01, 1992
Product Type:
Journal Article
Reference Number:
AIX-24-049043; EDB-93-092608
Resource Relation:
Journal Name: Monatshefte fuer Chemie; (Austria); Journal Volume: 123:10
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; CADMIUM COMPLEXES; TETRACYCLINES; COPPER COMPLEXES; LEAD COMPLEXES; URANYL COMPLEXES; AQUEOUS SOLUTIONS; POLAROGRAPHY; STABILITY; VOLTAMETRY; ACTINIDE COMPLEXES; ANTI-INFECTIVE AGENTS; ANTIBIOTICS; COMPLEXES; DISPERSIONS; DRUGS; MIXTURES; SOLUTIONS; TRANSITION ELEMENT COMPLEXES; URANIUM COMPLEXES; 400201* - Chemical & Physicochemical Properties
OSTI ID:
6341555
Country of Origin:
Austria
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0026-9247; CODEN: MOCHAP
Submitting Site:
INIS
Size:
Pages: 853-864
Announcement Date:
Aug 01, 1993

Journal Article:

Citation Formats

Ghandour, M A, Azab, H A, Hassan, A, and Ali, A M. Voltammetric studies on composition and stabilities of complexes of tetracycline and oxytetracycline with some metal ions in aqueous medium. Voltammetrische Untersuchungen zur Zusammensetzung und Stabilitaet von Komplexen von Tetracyclin und Oxytetracyclin mit einigen Metallionen in waessrigem Medium. Austria: N. p., 1992. Web.
Ghandour, M A, Azab, H A, Hassan, A, & Ali, A M. Voltammetric studies on composition and stabilities of complexes of tetracycline and oxytetracycline with some metal ions in aqueous medium. Voltammetrische Untersuchungen zur Zusammensetzung und Stabilitaet von Komplexen von Tetracyclin und Oxytetracyclin mit einigen Metallionen in waessrigem Medium. Austria.
Ghandour, M A, Azab, H A, Hassan, A, and Ali, A M. 1992. "Voltammetric studies on composition and stabilities of complexes of tetracycline and oxytetracycline with some metal ions in aqueous medium. Voltammetrische Untersuchungen zur Zusammensetzung und Stabilitaet von Komplexen von Tetracyclin und Oxytetracyclin mit einigen Metallionen in waessrigem Medium." Austria.
@misc{etde_6341555,
title = {Voltammetric studies on composition and stabilities of complexes of tetracycline and oxytetracycline with some metal ions in aqueous medium. Voltammetrische Untersuchungen zur Zusammensetzung und Stabilitaet von Komplexen von Tetracyclin und Oxytetracyclin mit einigen Metallionen in waessrigem Medium}
author = {Ghandour, M A, Azab, H A, Hassan, A, and Ali, A M}
abstractNote = {The composition and stability of complexes of tetracycline and oxytetracycline with Cu(II), Cd(II), Pb(II) and UO[sub 2](II) have been studied polarographically (direct current and differential pulse polarographic techniques) at 25[+-]0.1 deg C. Differential pulse polarographic studies have been particularly helpful in deciding the nature of metal-drug interactions at low concentrations. The reduction of Cu(II)-tetracycline has been found to be irreversible and diffusion controlled with the presence of an adsorption component. In the system uranyl(II)-tetracycline the complex formed has a stoichiometry of 1:1 and log K[sub ox] = 4.04 which is very close to that obtained by potentiometric measurements. The peak half width W[sub 1/2] of the Pb(II)-OTC system is 60-70 mV indicating that the process is reversible and two electrons are consumed. The log [beta]' is 10.30 in 0.1 mol dm[sup -3] NaClO[sub 4]. In the Cu(II)-OTC system two complexes were formed with log [beta][sub 1]' = 8.50 and log [beta][sub 2]' = 14.10. Cyclic voltammograms were recorded using a hanging dropping mercury electrode for the systems Cu(II), Cd(II), Pb(II) and UO[sub 2](II)-OTC to examine the irregularities in both peak potentials and peak currents during the polarographic investigations. (authors).}
journal = {Monatshefte fuer Chemie; (Austria)}
volume = {123:10}
journal type = {AC}
place = {Austria}
year = {1992}
month = {Jan}
}