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Quantitative assay for the number of leukemic spleen colony forming unit in radiation-induced murine myeloid leukemia

Journal Article:

Abstract

In mice with myelogenous leukemia, leukemic spleen colony forming units were assayed quantitatively. When 5 x 10/sup 3/ - 2 x 10/sup 4/ leukemic cells were transplanted to other mice of the same strain, a rectilinear relationship (p < 0.01) was found between the number of the cells transplanted and that of the colonies formed on the surface of the spleen. From these results, the authors considered that myelogenous leukemia in mice is an adequate model for acute myelogenous leukemia in human adults, and that the quantitative assay of the leukemic colony forming units can be used for sensitivity tests of antileukemic agents.
Authors:
Nara, N; [1]  Bessho, M
  1. Tokyo Medical and Dental Univ. (Japan). School of Medicine
Publication Date:
Nov 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-14-749757; EDB-83-098067
Resource Relation:
Journal Name: Igaku To Seibutsugaku; (Japan); Journal Volume: 103:5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MYELOID LEUKEMIA; BIOLOGICAL MODELS; SPLEEN COLONY FORMATION; BIOLOGICAL RADIATION EFFECTS; CFU; CHEMOTHERAPY; MICE; RADIATION CHIMERAS; SPLEEN; WEIGHT; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; BODY; CHIMERAS; COLONY FORMATION; DISEASES; ELECTROMAGNETIC RADIATION; HEMIC DISEASES; IONIZING RADIATIONS; LEUKEMIA; MAMMALS; MOSAICISM; NEOPLASMS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; THERAPY; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6339266
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: IGSBA
Submitting Site:
HEDB
Size:
Pages: 495-497
Announcement Date:

Journal Article:

Citation Formats

Nara, N, and Bessho, M. Quantitative assay for the number of leukemic spleen colony forming unit in radiation-induced murine myeloid leukemia. Japan: N. p., 1981. Web.
Nara, N, & Bessho, M. Quantitative assay for the number of leukemic spleen colony forming unit in radiation-induced murine myeloid leukemia. Japan.
Nara, N, and Bessho, M. 1981. "Quantitative assay for the number of leukemic spleen colony forming unit in radiation-induced murine myeloid leukemia." Japan.
@misc{etde_6339266,
title = {Quantitative assay for the number of leukemic spleen colony forming unit in radiation-induced murine myeloid leukemia}
author = {Nara, N, and Bessho, M}
abstractNote = {In mice with myelogenous leukemia, leukemic spleen colony forming units were assayed quantitatively. When 5 x 10/sup 3/ - 2 x 10/sup 4/ leukemic cells were transplanted to other mice of the same strain, a rectilinear relationship (p < 0.01) was found between the number of the cells transplanted and that of the colonies formed on the surface of the spleen. From these results, the authors considered that myelogenous leukemia in mice is an adequate model for acute myelogenous leukemia in human adults, and that the quantitative assay of the leukemic colony forming units can be used for sensitivity tests of antileukemic agents.}
journal = {Igaku To Seibutsugaku; (Japan)}
volume = {103:5}
journal type = {AC}
place = {Japan}
year = {1981}
month = {Nov}
}