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Immunohistochemical and radioimmunological demonstration of alpha/sub 1/-fetoprotein in nonmalignant changes of human gastric mucosa

Journal Article:

Abstract

The occurence of ..cap alpha../sub 1/ fetoprotein in nonmalignant changes of the gastric mucosa was investigated by means of immunohistochemistry and radioimmunonoassay. The investigations were performed in tissue sections, cytological imprint preparations as well as in homogenized tissue samples (obtained by gastroscopy). ..cap alpha../sub 1/ fetoprotein could be demonstrated by immuno-histochemistry in about 90% of the samples originating from the surroundings of gastric ulcer and the region of gastrojejunostomy after B II-resection. The RIA was positive in about 75% of the tissue samples, whereas from gastric juice only 40% of positive results could be obtained. No ..cap alpha../sub 1/ fetoprotein-activity could be demonstrated in serum samples. These investigations indicate that ..cap alpha../sub 1/ fetoprotein is not exclusively synthesized by embryonic or neoplastic tissues and also can be synthesized also by regenerating cell-systems. It may be supposed that this synthesis represents an unspecific answer to growth-stimulation.
Authors:
Falser, N; Lederer, B; Reissigl, H; [1]  Innsbruck Univ. (Austria). Gastroenterologisches Lab.)
  1. Innsbruck Univ. (Austria). Pathologisch-Anatomisches Lab.
Publication Date:
Jul 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-10-449028; EDB-79-075329
Resource Relation:
Journal Name: Klin. Wochenschr.; (Germany, Federal Republic of); Journal Volume: 55:13
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; GLOBULINS; RADIOIMMUNOASSAY; MUCOUS MEMBRANES; ANTIGEN-ANTIBODY REACTIONS; BODY FLUIDS; DIAGNOSIS; IODINE 125; NEOPLASMS; PATIENTS; STOMACH; TISSUES; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; GASTROINTESTINAL TRACT; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOASSAY; RADIOISOTOPES; TRACER TECHNIQUES; 550602* - Medicine- External Radiation in Diagnostics- (1980-)
OSTI ID:
6333448
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: CODEN: KLWOA
Submitting Site:
INIS
Size:
Pages: 635-640
Announcement Date:

Journal Article:

Citation Formats

Falser, N, Lederer, B, Reissigl, H, and Innsbruck Univ. (Austria). Gastroenterologisches Lab.). Immunohistochemical and radioimmunological demonstration of alpha/sub 1/-fetoprotein in nonmalignant changes of human gastric mucosa. Germany: N. p., 1977. Web.
Falser, N, Lederer, B, Reissigl, H, & Innsbruck Univ. (Austria). Gastroenterologisches Lab.). Immunohistochemical and radioimmunological demonstration of alpha/sub 1/-fetoprotein in nonmalignant changes of human gastric mucosa. Germany.
Falser, N, Lederer, B, Reissigl, H, and Innsbruck Univ. (Austria). Gastroenterologisches Lab.). 1977. "Immunohistochemical and radioimmunological demonstration of alpha/sub 1/-fetoprotein in nonmalignant changes of human gastric mucosa." Germany.
@misc{etde_6333448,
title = {Immunohistochemical and radioimmunological demonstration of alpha/sub 1/-fetoprotein in nonmalignant changes of human gastric mucosa}
author = {Falser, N, Lederer, B, Reissigl, H, and Innsbruck Univ. (Austria). Gastroenterologisches Lab.)}
abstractNote = {The occurence of ..cap alpha../sub 1/ fetoprotein in nonmalignant changes of the gastric mucosa was investigated by means of immunohistochemistry and radioimmunonoassay. The investigations were performed in tissue sections, cytological imprint preparations as well as in homogenized tissue samples (obtained by gastroscopy). ..cap alpha../sub 1/ fetoprotein could be demonstrated by immuno-histochemistry in about 90% of the samples originating from the surroundings of gastric ulcer and the region of gastrojejunostomy after B II-resection. The RIA was positive in about 75% of the tissue samples, whereas from gastric juice only 40% of positive results could be obtained. No ..cap alpha../sub 1/ fetoprotein-activity could be demonstrated in serum samples. These investigations indicate that ..cap alpha../sub 1/ fetoprotein is not exclusively synthesized by embryonic or neoplastic tissues and also can be synthesized also by regenerating cell-systems. It may be supposed that this synthesis represents an unspecific answer to growth-stimulation.}
journal = {Klin. Wochenschr.; (Germany, Federal Republic of)}
volume = {55:13}
journal type = {AC}
place = {Germany}
year = {1977}
month = {Jul}
}