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Effect of chemoradiotherapy using ACNU, vincristine, and nicardipine with high-dose irradiation on malignant astrocytomas

Abstract

Fifty-two patients with malignant astrocytoma were treated with cellular synchronization radiation therapy at the University of Tokyo Hospital between 1977 and 1989. Twenty-five patients (Group 1) received 1 - (4-amino-2-methyl-5-pyrimidinyl)methyl - 3 - (2-chloroethyl) - 3 - nitrosourea hydrochloride (ACNU), vincristine, and 60 Gy of irradiation, and 27 patients (Group 2) ACNU, vincristine, the Ca-channel blocker nicardipine, and 72 Gy of irradiation. Median survival times for Groups 1 and 2 were 15 and 30 months, respectively. Although there was no significant difference, Group 2 achieved longer survival with 1-, 2-, and 3-year survival rates of 85.2, 65.8, and 46.9% compared to rates of 66.7, 40.0, and 26.7%, respectively, for Group 1. (author).
Authors:
Genka, Shigeru; Shitara, Nobuyuki; Nakamura, Hirohiko; Takakura, Kintomo [1] 
  1. Tokyo Univ. (Japan). Hospital
Publication Date:
May 01, 1993
Product Type:
Journal Article
Reference Number:
JPN-93-007314; EDB-93-116898
Resource Relation:
Journal Name: Neurologia Medico-Chirurgica; (Japan); Journal Volume: 33:5
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ASTROCYTOMAS; RADIOTHERAPY; CHEMOTHERAPY; ANTINEOPLASTIC DRUGS; NITROSOUREAS; ONCOVIN; PATIENTS; RADIATION DOSES; SURVIVAL CURVES; SURVIVAL TIME; ALKALOIDS; ANTIMITOTIC DRUGS; DISEASES; DOSES; DRUGS; GLIOMAS; MEDICINE; NEOPLASMS; NITROSO COMPOUNDS; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOLOGY; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
6308501
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0387-2572; CODEN: NMCHBN
Submitting Site:
JPN
Size:
Pages: 295-299
Announcement Date:
Sep 15, 1993

Citation Formats

Genka, Shigeru, Shitara, Nobuyuki, Nakamura, Hirohiko, and Takakura, Kintomo. Effect of chemoradiotherapy using ACNU, vincristine, and nicardipine with high-dose irradiation on malignant astrocytomas. Japan: N. p., 1993. Web.
Genka, Shigeru, Shitara, Nobuyuki, Nakamura, Hirohiko, & Takakura, Kintomo. Effect of chemoradiotherapy using ACNU, vincristine, and nicardipine with high-dose irradiation on malignant astrocytomas. Japan.
Genka, Shigeru, Shitara, Nobuyuki, Nakamura, Hirohiko, and Takakura, Kintomo. 1993. "Effect of chemoradiotherapy using ACNU, vincristine, and nicardipine with high-dose irradiation on malignant astrocytomas." Japan.
@misc{etde_6308501,
title = {Effect of chemoradiotherapy using ACNU, vincristine, and nicardipine with high-dose irradiation on malignant astrocytomas}
author = {Genka, Shigeru, Shitara, Nobuyuki, Nakamura, Hirohiko, and Takakura, Kintomo}
abstractNote = {Fifty-two patients with malignant astrocytoma were treated with cellular synchronization radiation therapy at the University of Tokyo Hospital between 1977 and 1989. Twenty-five patients (Group 1) received 1 - (4-amino-2-methyl-5-pyrimidinyl)methyl - 3 - (2-chloroethyl) - 3 - nitrosourea hydrochloride (ACNU), vincristine, and 60 Gy of irradiation, and 27 patients (Group 2) ACNU, vincristine, the Ca-channel blocker nicardipine, and 72 Gy of irradiation. Median survival times for Groups 1 and 2 were 15 and 30 months, respectively. Although there was no significant difference, Group 2 achieved longer survival with 1-, 2-, and 3-year survival rates of 85.2, 65.8, and 46.9% compared to rates of 66.7, 40.0, and 26.7%, respectively, for Group 1. (author).}
journal = []
volume = {33:5}
journal type = {AC}
place = {Japan}
year = {1993}
month = {May}
}