Abstract
Fluorine-18 labelled haloperidol ( YF-HP) was synthesized by a fluorine-fluorine exchange reaction on haloperidol, fluorine-chlorine exchange on a chloro-analog of haloperidol, and from YF-labelled p-fluorobenzonitrile prepared by two different exchange reactions. Nucleophilic fluorine was used in the form of tetra n-butylammonium fluoride. The overall radiochemical yield, expressed at the end of syntheses was 5% for exchange in haloperidol and about 2%-3% for exchange in chloroanalog in a 40 min synthesis (from the end of the irradiation). Specific activities up to 1 Ci/mmol for haloperidol and up to 5000 Ci/mmol for chloro-analog as substrates were obtained. The syntheses using p-substituted chloro-and nitro-benzonitriles as starting materials for the exchange reaction gave a product with an average specific activity of about 2000 Ci/mmol and in general an overall radiochemical yield of 5%-10%. Purification of ( YF)haloperidol was done by HPLC on a C-18 column. The radiochemical purity as assessed by thin layer radiochromatography (TLRC) of the final product was at least 95%, with high chemical purity.
Citation Formats
Farrokhzad, S, and Diksic, M.
Synthesis of no-carrier-added and carrier-added YF-labelled haloperidol.
United Kingdom: N. p.,
1985.
Web.
doi:10.1002/jlcr.2580220713.
Farrokhzad, S, & Diksic, M.
Synthesis of no-carrier-added and carrier-added YF-labelled haloperidol.
United Kingdom.
https://doi.org/10.1002/jlcr.2580220713
Farrokhzad, S, and Diksic, M.
1985.
"Synthesis of no-carrier-added and carrier-added YF-labelled haloperidol."
United Kingdom.
https://doi.org/10.1002/jlcr.2580220713.
@misc{etde_6302693,
title = {Synthesis of no-carrier-added and carrier-added YF-labelled haloperidol}
author = {Farrokhzad, S, and Diksic, M}
abstractNote = {Fluorine-18 labelled haloperidol ( YF-HP) was synthesized by a fluorine-fluorine exchange reaction on haloperidol, fluorine-chlorine exchange on a chloro-analog of haloperidol, and from YF-labelled p-fluorobenzonitrile prepared by two different exchange reactions. Nucleophilic fluorine was used in the form of tetra n-butylammonium fluoride. The overall radiochemical yield, expressed at the end of syntheses was 5% for exchange in haloperidol and about 2%-3% for exchange in chloroanalog in a 40 min synthesis (from the end of the irradiation). Specific activities up to 1 Ci/mmol for haloperidol and up to 5000 Ci/mmol for chloro-analog as substrates were obtained. The syntheses using p-substituted chloro-and nitro-benzonitriles as starting materials for the exchange reaction gave a product with an average specific activity of about 2000 Ci/mmol and in general an overall radiochemical yield of 5%-10%. Purification of ( YF)haloperidol was done by HPLC on a C-18 column. The radiochemical purity as assessed by thin layer radiochromatography (TLRC) of the final product was at least 95%, with high chemical purity.}
doi = {10.1002/jlcr.2580220713}
journal = []
volume = {22:7}
journal type = {AC}
place = {United Kingdom}
year = {1985}
month = {Jul}
}
title = {Synthesis of no-carrier-added and carrier-added YF-labelled haloperidol}
author = {Farrokhzad, S, and Diksic, M}
abstractNote = {Fluorine-18 labelled haloperidol ( YF-HP) was synthesized by a fluorine-fluorine exchange reaction on haloperidol, fluorine-chlorine exchange on a chloro-analog of haloperidol, and from YF-labelled p-fluorobenzonitrile prepared by two different exchange reactions. Nucleophilic fluorine was used in the form of tetra n-butylammonium fluoride. The overall radiochemical yield, expressed at the end of syntheses was 5% for exchange in haloperidol and about 2%-3% for exchange in chloroanalog in a 40 min synthesis (from the end of the irradiation). Specific activities up to 1 Ci/mmol for haloperidol and up to 5000 Ci/mmol for chloro-analog as substrates were obtained. The syntheses using p-substituted chloro-and nitro-benzonitriles as starting materials for the exchange reaction gave a product with an average specific activity of about 2000 Ci/mmol and in general an overall radiochemical yield of 5%-10%. Purification of ( YF)haloperidol was done by HPLC on a C-18 column. The radiochemical purity as assessed by thin layer radiochromatography (TLRC) of the final product was at least 95%, with high chemical purity.}
doi = {10.1002/jlcr.2580220713}
journal = []
volume = {22:7}
journal type = {AC}
place = {United Kingdom}
year = {1985}
month = {Jul}
}