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Deposition and retention models for internal dosimetry of the human respiratory tract

Journal Article:

Abstract

A general overview of particulate deposition and clearance, particularly as related to radionuclides, but generally applicable is described. The respiratory system is divided into naso-pharynx (N-P) and tracheobronchial (T-B) (together constituting anatomical dead space and ciliated, mucus-covered portion) and pulmonary (caudally from respiratory bronchioles). N-P deposition (N) is expressed by: N = 0.62 + 0.475log(aerodynamic diameter)/sup 2/(inhalation, liters/min). T-B deposition calculated from anatomical and physical data (affected by hygroscopicity, especially for low-MW and low-density particles). Clearance mechanisms include: (1) a very rapid phase (minutes) for particles deposited on ciliated epithelium; (2) a rapid phase consisting of the slower elements of ciliary clearance and the rapidly recruitable phagocytes (transitional character of this phase makes it difficult to estimate half-time, 24 hr); (3) a slower alveolar phase dependent on properties of dust; (4) elimination via lymph. (3) and (4) have similar kinetics, but (3) is via T-B and GI.
Authors:
Publication Date:
Jan 01, 1966
Product Type:
Journal Article
Reference Number:
EDB-79-085295
Resource Relation:
Journal Name: Health Phys.; (United Kingdom); Journal Volume: 12
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RESPIRATORY SYSTEM; DOSIMETRY; RADIONUCLIDE KINETICS; LUNG CLEARANCE; MAN; RADIOISOTOPES; RETENTION; ANIMALS; CLEARANCE; EXCRETION; ISOTOPES; MAMMALS; PRIMATES; VERTEBRATES; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987); 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man
OSTI ID:
6288594
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: HLTPA
Submitting Site:
TIC
Size:
Pages: 173-207
Announcement Date:
Jul 01, 1979

Journal Article:

Citation Formats

Not Available. Deposition and retention models for internal dosimetry of the human respiratory tract. United Kingdom: N. p., 1966. Web.
Not Available. Deposition and retention models for internal dosimetry of the human respiratory tract. United Kingdom.
Not Available. 1966. "Deposition and retention models for internal dosimetry of the human respiratory tract." United Kingdom.
@misc{etde_6288594,
title = {Deposition and retention models for internal dosimetry of the human respiratory tract}
author = {Not Available}
abstractNote = {A general overview of particulate deposition and clearance, particularly as related to radionuclides, but generally applicable is described. The respiratory system is divided into naso-pharynx (N-P) and tracheobronchial (T-B) (together constituting anatomical dead space and ciliated, mucus-covered portion) and pulmonary (caudally from respiratory bronchioles). N-P deposition (N) is expressed by: N = 0.62 + 0.475log(aerodynamic diameter)/sup 2/(inhalation, liters/min). T-B deposition calculated from anatomical and physical data (affected by hygroscopicity, especially for low-MW and low-density particles). Clearance mechanisms include: (1) a very rapid phase (minutes) for particles deposited on ciliated epithelium; (2) a rapid phase consisting of the slower elements of ciliary clearance and the rapidly recruitable phagocytes (transitional character of this phase makes it difficult to estimate half-time, 24 hr); (3) a slower alveolar phase dependent on properties of dust; (4) elimination via lymph. (3) and (4) have similar kinetics, but (3) is via T-B and GI.}
journal = {Health Phys.; (United Kingdom)}
volume = {12}
journal type = {AC}
place = {United Kingdom}
year = {1966}
month = {Jan}
}