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Spreading of focal brain edema induced by ultraviolet irradiation

Journal Article:

Abstract

Focal brain edema limited to one cerebral hemisphere was produced by ultraviolet irradiation of the exposed cortex. Tissue water content was determined by the gravimetric method which allows microsampling. Therefore, the spread of edema around the small necrotic area be mapped more precisely than by determination of dry weight which calls for larger samples. As early as 30 min after irradiation, hyperemia and swelling of the brain are observed under the operating microscope. This correlates with venous stasis, hyperemia, and broadened perivascular spaces around venules and large capillaries accompanied by a marked rise in the specific weigth of the tissue. After 4h an edema front can be observed spreading from the perinerotic zone in which there is a marked rise in endothelial cell vesicular activity. Edema reaches maximum levels in the deep white matter at 48h post irradiation with normalisation of the tissue water content after 96h. The velocity at which the edema front spreads from the cortex to the periventricular area lies in the range of 0.25mm/h. Edema reabsorption coincides with signs of retrograde micropinocytosis in endothelial cells.
Authors:
Ferszt, R; Neu, S; Cervos-Navarro, J; Sperner, J [1] 
  1. Freie Univ. Berlin (Germany, F.R.). Inst. fuer Neuropathologie
Publication Date:
Jan 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-448575; EDB-79-075589
Resource Relation:
Journal Name: Acta Neuropathol.; (Germany, Federal Republic of); Journal Volume: 42:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BRAIN; DELAYED RADIATION EFFECTS; CEREBRAL CORTEX; EDEMA; ULTRAVIOLET RADIATION; BIOLOGICAL EFFECTS; CATS; INDUCTION; TIME DEPENDENCE; ULTRASTRUCTURAL CHANGES; ANIMALS; BIOLOGICAL RADIATION EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; CEREBRUM; DISEASES; ELECTROMAGNETIC RADIATION; MAMMALS; MORPHOLOGICAL CHANGES; NERVOUS SYSTEM; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIATIONS; SYMPTOMS; VERTEBRATES; 560400* - Other Environmental Pollutant Effects
OSTI ID:
6286720
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ANPTA
Submitting Site:
INIS
Size:
Pages: 223-229
Announcement Date:

Journal Article:

Citation Formats

Ferszt, R, Neu, S, Cervos-Navarro, J, and Sperner, J. Spreading of focal brain edema induced by ultraviolet irradiation. Germany: N. p., 1978. Web.
Ferszt, R, Neu, S, Cervos-Navarro, J, & Sperner, J. Spreading of focal brain edema induced by ultraviolet irradiation. Germany.
Ferszt, R, Neu, S, Cervos-Navarro, J, and Sperner, J. 1978. "Spreading of focal brain edema induced by ultraviolet irradiation." Germany.
@misc{etde_6286720,
title = {Spreading of focal brain edema induced by ultraviolet irradiation}
author = {Ferszt, R, Neu, S, Cervos-Navarro, J, and Sperner, J}
abstractNote = {Focal brain edema limited to one cerebral hemisphere was produced by ultraviolet irradiation of the exposed cortex. Tissue water content was determined by the gravimetric method which allows microsampling. Therefore, the spread of edema around the small necrotic area be mapped more precisely than by determination of dry weight which calls for larger samples. As early as 30 min after irradiation, hyperemia and swelling of the brain are observed under the operating microscope. This correlates with venous stasis, hyperemia, and broadened perivascular spaces around venules and large capillaries accompanied by a marked rise in the specific weigth of the tissue. After 4h an edema front can be observed spreading from the perinerotic zone in which there is a marked rise in endothelial cell vesicular activity. Edema reaches maximum levels in the deep white matter at 48h post irradiation with normalisation of the tissue water content after 96h. The velocity at which the edema front spreads from the cortex to the periventricular area lies in the range of 0.25mm/h. Edema reabsorption coincides with signs of retrograde micropinocytosis in endothelial cells.}
journal = {Acta Neuropathol.; (Germany, Federal Republic of)}
volume = {42:3}
journal type = {AC}
place = {Germany}
year = {1978}
month = {Jan}
}