You need JavaScript to view this

Inhibitory effect of unlabeled iodothyronines on the deiodination of labeled thyroid hormones by cultured hepatocarcinoma cells

Journal Article:

Abstract

Inhibitory effects of unlabeled iodothyronines on the metabolism of thyroxine (T/sub 4/), 3,3',5-triiodothyronine (T/sub 3/) and 3,3',5'-triiodothyronine (reverse T/sub 3/, rT/sub 3/) were investigated in continuously cultured monkey hepatocarcinoma cells which showed a rapid metabolism of the thyroid hormones. Nonphenolic ring deiodination of (3',5'-/sup 125/I)-T/sub 4/ and (3'-/sup 125/I)-T/sub 3/ was strongly inhibited by excess T/sub 3/, 3,5-diiodothyronine (3,5-T/sub 2/) and T/sub 4/, whereas rT/sub 3/ was the least effective inhibitor. Phenolic ring deiodination of (3',5'-/sup 125/I)-rT/sub 3/ was strongly affected by excess unlabeled rT/sub 3/. However, the inhibitory effect of T/sub 4/, T/sub 3/ and 3,5-T/sub 3/ was much weaker than that of rT/sub 3/. It was concluded that rT/sub 3/ is apparently the most effective inhibitor of phenolic ring deiodination but the least effective inhibitor of nonphenolic ring deiodination.
Authors:
Sorimachi, K [1] 
  1. Dokkyo Univ. Tochigi (Japan). School of Medicine
Publication Date:
Apr 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-12-607523; EDB-81-100650
Resource Relation:
Journal Name: Endocrinol. Jpn.; (Japan); Journal Volume: 27:2
Subject:
59 BASIC BIOLOGICAL SCIENCES; DEIODINATION; TRACER TECHNIQUES; TRIIODOTHYRONINE; METABOLISM; BIOLOGICAL PATHWAYS; HEPATOMAS; INHIBITION; IODINE 125; ION EXCHANGE CHROMATOGRAPHY; LABELLED COMPOUNDS; MONKEYS; THIN-LAYER CHROMATOGRAPHY; THYROXINE; TUMOR CELLS; AMINO ACIDS; ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; CHROMATOGRAPHY; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; HORMONES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; PEPTIDE HORMONES; PRIMATES; RADIOISOTOPES; SEPARATION PROCESSES; THYROID HORMONES; VERTEBRATES; 550501* - Metabolism- Tracer Techniques
OSTI ID:
6281876
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ECJPA
Submitting Site:
INIS
Size:
Pages: 209-214
Announcement Date:

Journal Article:

Citation Formats

Sorimachi, K. Inhibitory effect of unlabeled iodothyronines on the deiodination of labeled thyroid hormones by cultured hepatocarcinoma cells. Japan: N. p., 1980. Web.
Sorimachi, K. Inhibitory effect of unlabeled iodothyronines on the deiodination of labeled thyroid hormones by cultured hepatocarcinoma cells. Japan.
Sorimachi, K. 1980. "Inhibitory effect of unlabeled iodothyronines on the deiodination of labeled thyroid hormones by cultured hepatocarcinoma cells." Japan.
@misc{etde_6281876,
title = {Inhibitory effect of unlabeled iodothyronines on the deiodination of labeled thyroid hormones by cultured hepatocarcinoma cells}
author = {Sorimachi, K}
abstractNote = {Inhibitory effects of unlabeled iodothyronines on the metabolism of thyroxine (T/sub 4/), 3,3',5-triiodothyronine (T/sub 3/) and 3,3',5'-triiodothyronine (reverse T/sub 3/, rT/sub 3/) were investigated in continuously cultured monkey hepatocarcinoma cells which showed a rapid metabolism of the thyroid hormones. Nonphenolic ring deiodination of (3',5'-/sup 125/I)-T/sub 4/ and (3'-/sup 125/I)-T/sub 3/ was strongly inhibited by excess T/sub 3/, 3,5-diiodothyronine (3,5-T/sub 2/) and T/sub 4/, whereas rT/sub 3/ was the least effective inhibitor. Phenolic ring deiodination of (3',5'-/sup 125/I)-rT/sub 3/ was strongly affected by excess unlabeled rT/sub 3/. However, the inhibitory effect of T/sub 4/, T/sub 3/ and 3,5-T/sub 3/ was much weaker than that of rT/sub 3/. It was concluded that rT/sub 3/ is apparently the most effective inhibitor of phenolic ring deiodination but the least effective inhibitor of nonphenolic ring deiodination.}
journal = {Endocrinol. Jpn.; (Japan)}
volume = {27:2}
journal type = {AC}
place = {Japan}
year = {1980}
month = {Apr}
}