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Osteoarticular complications in sicklemic patients after childhood. Diagnostic problems

Journal Article:

Abstract

The osteoarticular complications of drepanocytosis-thalassemia (DT) include: (1) infarction, or avascular necrosis (AVN), common at all ages; (2) acute septic arthritis and hematogenous osteomyelitis, that usually affect infants and children. Early diagnosis and treatment of the osteoarticular infectious complications is imperative, to maximize the chances of a favorable outcome, and to prevent the sequelae, i.e. pathological fractures, chronic osteomyelitis. Early roentgenographic features of involved areas are similar in acute osteomyelitis and in AVN-both of which cause painfull bone crises, so as to make osteomyelites (OM) a diagnostic challenge. Four cases of DT are reported. The patients, 17 to 37 years old, presented with bone infarcts. One of them (the youngest) had also multiple osteomyelitis of long bones. The 99m-Tc-MDP bone scans, performed only on the youngest patient, affected by OM, revealed increased uptake in both AVN and in OM locations, without differential diagnostic features. After a review of the literature, a diagnostic protocol is suggested, based on 99m-Tc-nanocolloid marrow scintigraphy for the early differential diagnosis between acute OM (normal or slightly-increased uptake), chronic OM (markedly increased uptake) and AVN (decreased uptake). Furthermore, MR imaging is stressed as the most promising tool, in the next future, for this kind of different  More>>
Authors:
Publication Date:
Jan 01, 1988
Product Type:
Journal Article
Reference Number:
AIX-20-037285; EDB-89-073538
Resource Relation:
Journal Name: Radiol. Med.; (Italy); Journal Volume: 76:5
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOMEDICAL RADIOGRAPHY; THALASSEMIA; MAGNETIC RESONANCE; OSTEOMYELITIS; SCINTISCANNING; SKELETON; ANEMIAS; BODY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; HEMIC DISEASES; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIOISOTOPE SCANNING; RADIOLOGY; RESONANCE; SKELETAL DISEASES; SYMPTOMS; 550602* - Medicine- External Radiation in Diagnostics- (1980-)
OSTI ID:
6278036
Research Organizations:
Rome Univ. (Italy). I Cattedra di Radiologia e Cattedra di Ematologia
Country of Origin:
Italy
Language:
Italian
Other Identifying Numbers:
Journal ID: CODEN: RAMEA
Submitting Site:
INIS
Size:
Pages: 409-413
Announcement Date:

Journal Article:

Citation Formats

Potente, G. Osteoarticular complications in sicklemic patients after childhood. Diagnostic problems. Italy: N. p., 1988. Web.
Potente, G. Osteoarticular complications in sicklemic patients after childhood. Diagnostic problems. Italy.
Potente, G. 1988. "Osteoarticular complications in sicklemic patients after childhood. Diagnostic problems." Italy.
@misc{etde_6278036,
title = {Osteoarticular complications in sicklemic patients after childhood. Diagnostic problems}
author = {Potente, G}
abstractNote = {The osteoarticular complications of drepanocytosis-thalassemia (DT) include: (1) infarction, or avascular necrosis (AVN), common at all ages; (2) acute septic arthritis and hematogenous osteomyelitis, that usually affect infants and children. Early diagnosis and treatment of the osteoarticular infectious complications is imperative, to maximize the chances of a favorable outcome, and to prevent the sequelae, i.e. pathological fractures, chronic osteomyelitis. Early roentgenographic features of involved areas are similar in acute osteomyelitis and in AVN-both of which cause painfull bone crises, so as to make osteomyelites (OM) a diagnostic challenge. Four cases of DT are reported. The patients, 17 to 37 years old, presented with bone infarcts. One of them (the youngest) had also multiple osteomyelitis of long bones. The 99m-Tc-MDP bone scans, performed only on the youngest patient, affected by OM, revealed increased uptake in both AVN and in OM locations, without differential diagnostic features. After a review of the literature, a diagnostic protocol is suggested, based on 99m-Tc-nanocolloid marrow scintigraphy for the early differential diagnosis between acute OM (normal or slightly-increased uptake), chronic OM (markedly increased uptake) and AVN (decreased uptake). Furthermore, MR imaging is stressed as the most promising tool, in the next future, for this kind of different diagnosis. 23 refs.}
journal = {Radiol. Med.; (Italy)}
volume = {76:5}
journal type = {AC}
place = {Italy}
year = {1988}
month = {Jan}
}