Abstract
The syntheses of ({sup 13}C)- and ({sup 14}C)ellagic acid (EA) were accomplished by reacting ({sup 13}C)- or ({sup 14}C)CO{sub 2} with metalated 3,4,5-trimethoxybenzene to afford trimethylgallic acid which was O-demethylated with hydroiodic acid. Oxidation of the resulting labeled gallic acid with potassium persulfate produced EA. The yields of trimethylgallic acid and EA based on ({sup 14}C)BaCo{sub 3} are 48 and 1% respectively. Final purification of EA involved the use of preparative reversed-phase HPLC and removal of the eluent buffer salts on a C{sub 18} Sep-Pak column. The isotopic purity of ({sup 13}C)EA was determined by {sup 13}C NMR. The ({sup 14}C)EA had 99% radiochemical purity as determined by analytical HPLC and a specific activity of ca. 110 mCi/mmol. (author).
Citation Formats
Mishra, N C, and Gold, B.
Synthesis of sup 13 C- and sup 14 C-labeled ellagic acid.
United Kingdom: N. p.,
1990.
Web.
doi:10.1002/jlcr.2580280807.
Mishra, N C, & Gold, B.
Synthesis of sup 13 C- and sup 14 C-labeled ellagic acid.
United Kingdom.
https://doi.org/10.1002/jlcr.2580280807
Mishra, N C, and Gold, B.
1990.
"Synthesis of sup 13 C- and sup 14 C-labeled ellagic acid."
United Kingdom.
https://doi.org/10.1002/jlcr.2580280807.
@misc{etde_6258045,
title = {Synthesis of sup 13 C- and sup 14 C-labeled ellagic acid}
author = {Mishra, N C, and Gold, B}
abstractNote = {The syntheses of ({sup 13}C)- and ({sup 14}C)ellagic acid (EA) were accomplished by reacting ({sup 13}C)- or ({sup 14}C)CO{sub 2} with metalated 3,4,5-trimethoxybenzene to afford trimethylgallic acid which was O-demethylated with hydroiodic acid. Oxidation of the resulting labeled gallic acid with potassium persulfate produced EA. The yields of trimethylgallic acid and EA based on ({sup 14}C)BaCo{sub 3} are 48 and 1% respectively. Final purification of EA involved the use of preparative reversed-phase HPLC and removal of the eluent buffer salts on a C{sub 18} Sep-Pak column. The isotopic purity of ({sup 13}C)EA was determined by {sup 13}C NMR. The ({sup 14}C)EA had 99% radiochemical purity as determined by analytical HPLC and a specific activity of ca. 110 mCi/mmol. (author).}
doi = {10.1002/jlcr.2580280807}
journal = []
volume = {28:8}
journal type = {AC}
place = {United Kingdom}
year = {1990}
month = {Aug}
}
title = {Synthesis of sup 13 C- and sup 14 C-labeled ellagic acid}
author = {Mishra, N C, and Gold, B}
abstractNote = {The syntheses of ({sup 13}C)- and ({sup 14}C)ellagic acid (EA) were accomplished by reacting ({sup 13}C)- or ({sup 14}C)CO{sub 2} with metalated 3,4,5-trimethoxybenzene to afford trimethylgallic acid which was O-demethylated with hydroiodic acid. Oxidation of the resulting labeled gallic acid with potassium persulfate produced EA. The yields of trimethylgallic acid and EA based on ({sup 14}C)BaCo{sub 3} are 48 and 1% respectively. Final purification of EA involved the use of preparative reversed-phase HPLC and removal of the eluent buffer salts on a C{sub 18} Sep-Pak column. The isotopic purity of ({sup 13}C)EA was determined by {sup 13}C NMR. The ({sup 14}C)EA had 99% radiochemical purity as determined by analytical HPLC and a specific activity of ca. 110 mCi/mmol. (author).}
doi = {10.1002/jlcr.2580280807}
journal = []
volume = {28:8}
journal type = {AC}
place = {United Kingdom}
year = {1990}
month = {Aug}
}