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Assessment of the specificity of norethisterone radioimmunoassays

Abstract

It is concluded that (1) the significance of cross- reaction studies as well as that of the parallelism test for the assessment of the over-all specificity of the assay is limited, (2) a single chromatography prior to the radioimmunoassay proper improves the assay specificity, but may not be sufficient to remove all interfering compounds, (3) a comparison of the direct and chromatographic assay procedures using several antisera is useful for the selection of the relatively most specific radioimmunoassay procedure. In the present study, this is the technique employing either antiserum C or antiserum D, the latter, however, only after chromatography.
Authors:
Bedolla-Tovar, N; Rahman, S A; Cekan, S Z; Diczfalusy, E [1] 
  1. Swedish Medical Research Council, Karolinska Hospital, Stockholm
Publication Date:
Jun 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-452229; EDB-79-096180
Resource Relation:
Journal Name: J. Steroid Biochem.; (United Kingdom); Journal Volume: 9:6
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; RADIOIMMUNOASSAY; SPECIFICITY; STEROID HORMONES; ALBUMINS; BLOOD PLASMA; BLOOD SERUM; CATTLE; COMPARATIVE EVALUATIONS; DRUGS; IMMUNE SERUMS; INHIBITION; OVULATION; PREGNANCY; WOMEN; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BODY FLUIDS; DOMESTIC ANIMALS; FEMALES; HORMONES; ISOTOPE APPLICATIONS; MAMMALS; MAN; ORGANIC COMPOUNDS; PRIMATES; PROTEINS; RADIOASSAY; RUMINANTS; TRACER TECHNIQUES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6255667
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JSTBB
Submitting Site:
INIS
Size:
Pages: 561-567
Announcement Date:
May 01, 1979

Citation Formats

Bedolla-Tovar, N, Rahman, S A, Cekan, S Z, and Diczfalusy, E. Assessment of the specificity of norethisterone radioimmunoassays. United Kingdom: N. p., 1978. Web. doi:10.1016/0022-4731(78)90123-1.
Bedolla-Tovar, N, Rahman, S A, Cekan, S Z, & Diczfalusy, E. Assessment of the specificity of norethisterone radioimmunoassays. United Kingdom. doi:10.1016/0022-4731(78)90123-1.
Bedolla-Tovar, N, Rahman, S A, Cekan, S Z, and Diczfalusy, E. 1978. "Assessment of the specificity of norethisterone radioimmunoassays." United Kingdom. doi:10.1016/0022-4731(78)90123-1. https://www.osti.gov/servlets/purl/10.1016/0022-4731(78)90123-1.
@misc{etde_6255667,
title = {Assessment of the specificity of norethisterone radioimmunoassays}
author = {Bedolla-Tovar, N, Rahman, S A, Cekan, S Z, and Diczfalusy, E}
abstractNote = {It is concluded that (1) the significance of cross- reaction studies as well as that of the parallelism test for the assessment of the over-all specificity of the assay is limited, (2) a single chromatography prior to the radioimmunoassay proper improves the assay specificity, but may not be sufficient to remove all interfering compounds, (3) a comparison of the direct and chromatographic assay procedures using several antisera is useful for the selection of the relatively most specific radioimmunoassay procedure. In the present study, this is the technique employing either antiserum C or antiserum D, the latter, however, only after chromatography.}
doi = {10.1016/0022-4731(78)90123-1}
journal = {J. Steroid Biochem.; (United Kingdom)}
volume = {9:6}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Jun}
}