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Environmental factors and leukaemia

Journal Article:

Abstract

Investigations on the association between environmental hazards and the development of various types of leukaemia are reviewed. Regarding acute non-lymphocytic leukaemia (ANLL) exposure to ionizing radiation is a well-documented risk factor. According to several recent studies exposure to strong electromagnetic fields may be suspected to be of etiologic importance for ANLL. There is evidence that occupational handling of benzene is a risk factor and other organic solvents may also be leukaemogenic. Occupational exposure to petrol products has been proposed to be a risk factor although the hazardous substances have not yet been defined. Results of cytogenetic studies in ANLL suggest that exposure to certain environmental agents may be associated with relatively specific clonal chromosome aberrations. Exposure in utero to ionizing radiation has been proposed to be a risk factor for acute lymphocytic leukaemia (ALL) in children. Unlike ANLL there seems at present to be little evidence that ALL is related to exposure to some chemicals. Chronic myeloid leukaemia (CML) may follow exposure to high doses of ionizing radiation whereas such exposure seems to be of insignificant importance for the development of chronic lymphocytic leukaemia (CLL). According to some studies an abnormally high incidence of CLL may be found among farmers  More>>
Authors:
Publication Date:
Jan 01, 1985
Product Type:
Journal Article
Reference Number:
EDB-86-044763
Resource Relation:
Journal Name: Med. Oncol. Tumor Pharmacoth.; (United Kingdom); Journal Volume: 1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BENZENE; ENVIRONMENTAL EXPOSURE; OCCUPATIONAL EXPOSURE; GASOLINE; IONIZING RADIATIONS; LEUKEMIA; RISK ASSESSMENT; CATTLE; CHROMOSOMAL ABERRATIONS; PREGNANCY; ANIMALS; AROMATICS; DISEASES; DOMESTIC ANIMALS; FUELS; HEMIC DISEASES; HYDROCARBONS; LIQUID FUELS; MAMMALS; MUTATIONS; NEOPLASMS; ORGANIC COMPOUNDS; PETROLEUM PRODUCTS; RADIATIONS; RUMINANTS; VERTEBRATES; 560151* - Radiation Effects on Animals- Man; 560306 - Chemicals Metabolism & Toxicology- Man- (-1987)
OSTI ID:
6255095
Research Organizations:
Univ. Hospital, Lund, Sweden
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: MOTPE
Submitting Site:
HEDB
Size:
Pages: 7-10
Announcement Date:

Journal Article:

Citation Formats

Brandt, L. Environmental factors and leukaemia. United Kingdom: N. p., 1985. Web.
Brandt, L. Environmental factors and leukaemia. United Kingdom.
Brandt, L. 1985. "Environmental factors and leukaemia." United Kingdom.
@misc{etde_6255095,
title = {Environmental factors and leukaemia}
author = {Brandt, L}
abstractNote = {Investigations on the association between environmental hazards and the development of various types of leukaemia are reviewed. Regarding acute non-lymphocytic leukaemia (ANLL) exposure to ionizing radiation is a well-documented risk factor. According to several recent studies exposure to strong electromagnetic fields may be suspected to be of etiologic importance for ANLL. There is evidence that occupational handling of benzene is a risk factor and other organic solvents may also be leukaemogenic. Occupational exposure to petrol products has been proposed to be a risk factor although the hazardous substances have not yet been defined. Results of cytogenetic studies in ANLL suggest that exposure to certain environmental agents may be associated with relatively specific clonal chromosome aberrations. Exposure in utero to ionizing radiation has been proposed to be a risk factor for acute lymphocytic leukaemia (ALL) in children. Unlike ANLL there seems at present to be little evidence that ALL is related to exposure to some chemicals. Chronic myeloid leukaemia (CML) may follow exposure to high doses of ionizing radiation whereas such exposure seems to be of insignificant importance for the development of chronic lymphocytic leukaemia (CLL). According to some studies an abnormally high incidence of CLL may be found among farmers in the USA. These results have not been confirmed in Scandinavian studies. There seems to be little evidence that CML or CLL are related to occupational handling of some chemicals. 35 references.}
journal = {Med. Oncol. Tumor Pharmacoth.; (United Kingdom)}
volume = {1}
journal type = {AC}
place = {United Kingdom}
year = {1985}
month = {Jan}
}