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Quantitative analysis of the clinical data on leukemia, 5. Specificity of clinical features in acute myelocytic leukemia with 8; 21 translocation by multiple logistic discriminant analysis

Journal Article:

Abstract

In order to determine the necessity of chromosome analysis required for the evaluation of 8;21 translocation, multiple logistic discriminant analysis was made on 124 patients with acute non-lymphocytic leukemia experienced in the authors' institution. Variables which showed positive correlation with the presence of 8;21 translocation were the presence of Auer body and granular abnormality of the cells, numbers of peripheral promyelocytes, myelocytes and metamyelocytes, and bone marrow promyelocytes, myelocytes, and the sum of rods and segments. Those which showed negative correlation with 8;21 translocation were peripheral platelet count, neutrocytealkaline phosphatase (N-AP) score, numbers of eosinocytes, monocytes and erythroblasts, and erythroblasts on myelogram. Auer body, four peripheral hematological features (platelet count, N-AP score, metamyelocytes and monocytes), and three myelogram features (myelocytes, reticular cells and granulocytes/eosionocytes) were used for the multiple logistic discriminant analysis. By the analysis, 2 of the 22 patients (9.1%) with translocation were judged not to have 8;21 translocation and 3 of the 102 patients (2.9%) without translocation were judged to have it. Therefore, this multiple logistic discriminant method has proved to be simple and useful in clinically evaluating acute non-lymphocytic leukemia. (Namekawa, K.).
Publication Date:
Nov 01, 1984
Product Type:
Journal Article
Reference Number:
AIX-17-006298; EDB-86-044769
Resource Relation:
Journal Name: Hiroshima Igaku; (Japan); Journal Volume: 37:11
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; MYELOID LEUKEMIA; CHROMOSOMAL ABERRATIONS; CORRELATIONS; BLOOD CHEMISTRY; BLOOD PLATELETS; BONE MARROW CELLS; CHROMOSOMES; REGRESSION ANALYSIS; ANIMAL CELLS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; HEMIC DISEASES; HUMAN POPULATIONS; LEUKEMIA; MATERIALS; MATHEMATICS; MUTATIONS; NEOPLASMS; POPULATIONS; SOMATIC CELLS; STATISTICS; 560151* - Radiation Effects on Animals- Man
OSTI ID:
6255059
Research Organizations:
Hiroshima Univ., Japan. Research Inst. for Nuclear Medicine and Biology
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: HIRGA
Submitting Site:
HEDB
Size:
Pages: 1543-1549
Announcement Date:

Journal Article:

Citation Formats

Ueoka, Hiroshi, Kamada, Nanao, Yamamoto, Hisashi, Ohtaki, Megu, Takimoto, Yasuo, Kuramoto, Atsushi, and Munaka, Masaki. Quantitative analysis of the clinical data on leukemia, 5. Specificity of clinical features in acute myelocytic leukemia with 8; 21 translocation by multiple logistic discriminant analysis. Japan: N. p., 1984. Web.
Ueoka, Hiroshi, Kamada, Nanao, Yamamoto, Hisashi, Ohtaki, Megu, Takimoto, Yasuo, Kuramoto, Atsushi, & Munaka, Masaki. Quantitative analysis of the clinical data on leukemia, 5. Specificity of clinical features in acute myelocytic leukemia with 8; 21 translocation by multiple logistic discriminant analysis. Japan.
Ueoka, Hiroshi, Kamada, Nanao, Yamamoto, Hisashi, Ohtaki, Megu, Takimoto, Yasuo, Kuramoto, Atsushi, and Munaka, Masaki. 1984. "Quantitative analysis of the clinical data on leukemia, 5. Specificity of clinical features in acute myelocytic leukemia with 8; 21 translocation by multiple logistic discriminant analysis." Japan.
@misc{etde_6255059,
title = {Quantitative analysis of the clinical data on leukemia, 5. Specificity of clinical features in acute myelocytic leukemia with 8; 21 translocation by multiple logistic discriminant analysis}
author = {Ueoka, Hiroshi, Kamada, Nanao, Yamamoto, Hisashi, Ohtaki, Megu, Takimoto, Yasuo, Kuramoto, Atsushi, and Munaka, Masaki}
abstractNote = {In order to determine the necessity of chromosome analysis required for the evaluation of 8;21 translocation, multiple logistic discriminant analysis was made on 124 patients with acute non-lymphocytic leukemia experienced in the authors' institution. Variables which showed positive correlation with the presence of 8;21 translocation were the presence of Auer body and granular abnormality of the cells, numbers of peripheral promyelocytes, myelocytes and metamyelocytes, and bone marrow promyelocytes, myelocytes, and the sum of rods and segments. Those which showed negative correlation with 8;21 translocation were peripheral platelet count, neutrocytealkaline phosphatase (N-AP) score, numbers of eosinocytes, monocytes and erythroblasts, and erythroblasts on myelogram. Auer body, four peripheral hematological features (platelet count, N-AP score, metamyelocytes and monocytes), and three myelogram features (myelocytes, reticular cells and granulocytes/eosionocytes) were used for the multiple logistic discriminant analysis. By the analysis, 2 of the 22 patients (9.1%) with translocation were judged not to have 8;21 translocation and 3 of the 102 patients (2.9%) without translocation were judged to have it. Therefore, this multiple logistic discriminant method has proved to be simple and useful in clinically evaluating acute non-lymphocytic leukemia. (Namekawa, K.).}
journal = {Hiroshima Igaku; (Japan)}
volume = {37:11}
journal type = {AC}
place = {Japan}
year = {1984}
month = {Nov}
}