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Chromosome radiosensitivity and kinetics of proliferation of peripheral lymphocytes in individuals with aneuploid karyotype

Journal Article:

Abstract

Experimentally investigated was the radiosensitivity of chromosomes and the kinetics of the proliferation of peripheral lymphocytes in patients with aneuploid (DS and TS) and normal karyotype irradiated in vitro in the G/sub o/ stage of the cell cycle. Trisomic lymphocytes were found to proliferate more rapidly in the in vitro culture and to be more sensitive than diploid cell populations. In monosomic lymphocytes in Turner syndrome patients, the proliferation and incidence of chromosomal abberations was similar to the disomic lines in Down's syndrome patients and in Turner syndrome patients, and to that found in persons with a normal karyotype. The results of the experiment show that there is a relationship between the proliferation rate of peripheral lymphocytes cultures in vitro and the radiosensivity of chromosomes. (author). 1 tab., 3 figs., 11 refs.
Publication Date:
Aug 01, 1988
Product Type:
Journal Article
Reference Number:
AIX-20-048503; EDB-89-094735
Resource Relation:
Journal Name: Bratisl. Lek. Listy; (Czechoslovakia); Journal Volume: 89:8; Other Information: English translation available from Nuclear Information Center, 156 16 Prague 5-Zbraslav, Czechoslovakia at US$ 10 per page
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DICENTRIC CHROMOSOMES; RADIOSENSITIVITY; LYMPHOCYTES; CELL PROLIFERATION; ANEUPLOIDY; BIOLOGICAL RADIATION EFFECTS; CHROMATIDS; CHROMOSOMAL ABERRATIONS; DOWNS SYNDROME; IN VITRO; ANIMAL CELLS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CHROMOSOMES; CONGENITAL MALFORMATIONS; CONNECTIVE TISSUE CELLS; DISEASES; HEREDITARY DISEASES; LEUKOCYTES; MALFORMATIONS; MATERIALS; MUTATIONS; PATHOLOGICAL CHANGES; PLOIDY; RADIATION EFFECTS; SOMATIC CELLS; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture
OSTI ID:
6253359
Country of Origin:
Serbia and Montenegro
Language:
Slovak
Other Identifying Numbers:
Journal ID: CODEN: BLLIA
Submitting Site:
INIS
Size:
Pages: 615-618
Announcement Date:

Journal Article:

Citation Formats

Konecna, H, Kalina, I, and Ondrussekova, A. Chromosome radiosensitivity and kinetics of proliferation of peripheral lymphocytes in individuals with aneuploid karyotype. Serbia and Montenegro: N. p., 1988. Web.
Konecna, H, Kalina, I, & Ondrussekova, A. Chromosome radiosensitivity and kinetics of proliferation of peripheral lymphocytes in individuals with aneuploid karyotype. Serbia and Montenegro.
Konecna, H, Kalina, I, and Ondrussekova, A. 1988. "Chromosome radiosensitivity and kinetics of proliferation of peripheral lymphocytes in individuals with aneuploid karyotype." Serbia and Montenegro.
@misc{etde_6253359,
title = {Chromosome radiosensitivity and kinetics of proliferation of peripheral lymphocytes in individuals with aneuploid karyotype}
author = {Konecna, H, Kalina, I, and Ondrussekova, A}
abstractNote = {Experimentally investigated was the radiosensitivity of chromosomes and the kinetics of the proliferation of peripheral lymphocytes in patients with aneuploid (DS and TS) and normal karyotype irradiated in vitro in the G/sub o/ stage of the cell cycle. Trisomic lymphocytes were found to proliferate more rapidly in the in vitro culture and to be more sensitive than diploid cell populations. In monosomic lymphocytes in Turner syndrome patients, the proliferation and incidence of chromosomal abberations was similar to the disomic lines in Down's syndrome patients and in Turner syndrome patients, and to that found in persons with a normal karyotype. The results of the experiment show that there is a relationship between the proliferation rate of peripheral lymphocytes cultures in vitro and the radiosensivity of chromosomes. (author). 1 tab., 3 figs., 11 refs.}
journal = {Bratisl. Lek. Listy; (Czechoslovakia)}
volume = {89:8}
journal type = {AC}
place = {Serbia and Montenegro}
year = {1988}
month = {Aug}
}