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Development of Tc-99m-DTPA-HSA as a new blood pool scanning agent

Journal Article:

Abstract

A new HSA preparation, Tc-99m-DTPA-HSA, was developed as a blood pool scanning agent. It shows higher labeling yield (more than 95 %) and higher blood retention (74.7 % I.D. at 1 hour post-injection) than Tc-99m-HSA prepared by directly labeling of HSA with Tc-99m. The introduction of DTPA, a strong bifunctional chelating agent, to HSA provides sites for the stable binding of Tc-99m. The preparation composed of 20 mCi of Tc-99m at calibration time and 10 mg of DTPA-HSA in a vial. After labeling, it had been stable for 24 hours at room temperature. In rats, most of Tc-99m-DTPA-HSA injected was metabolized and excreted in urine and feces. The cumulative radioactivity in urine and feces were 56.0 % and 13.7 % of injected dose, respectively, at 48 hours after injection. Metabolites observed in urine were Tc-99m-urea, Tc-99m-DTPA, reduced Tc-99m and so on. Tc-99m-DTPA-HSA proved, thus, a desirable feature for the blood pool scanning agent.
Publication Date:
Apr 01, 1987
Product Type:
Journal Article
Reference Number:
JPN-87-060094; EDB-87-163933
Resource Relation:
Journal Name: Kaku Igaku; (Japan); Journal Volume: 24:4
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 62 RADIOLOGY AND NUCLEAR MEDICINE; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; TECHNETIUM 99; DIAGNOSTIC USES; ALBUMINS; BLOOD SERUM; BLOOD-PLASMA CLEARANCE; DTPA; HEART; ISOMERIC NUCLEI; RADIOCARDIOGRAPHY; RATS; RETENTION; TIME DEPENDENCE; TISSUE DISTRIBUTION; AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CARDIOGRAPHY; CARDIOVASCULAR SYSTEM; CHELATING AGENTS; CLEARANCE; DIAGNOSTIC TECHNIQUES; DISTRIBUTION; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RODENTS; SYNTHESIS; TECHNETIUM ISOTOPES; USES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials; 550601 - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6250490
Research Organizations:
Nihon Medi-Physics Co. Ltd., Sodegaura, Chiba, Japan
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: KAIGB
Submitting Site:
JPN
Size:
Pages: 475-478
Announcement Date:

Journal Article:

Citation Formats

Shirakami, Y, Matsumoto, Y, Yamauchi, Y, Kurami, M, Ueda, N, and Hazue, M. Development of Tc-99m-DTPA-HSA as a new blood pool scanning agent. Japan: N. p., 1987. Web.
Shirakami, Y, Matsumoto, Y, Yamauchi, Y, Kurami, M, Ueda, N, & Hazue, M. Development of Tc-99m-DTPA-HSA as a new blood pool scanning agent. Japan.
Shirakami, Y, Matsumoto, Y, Yamauchi, Y, Kurami, M, Ueda, N, and Hazue, M. 1987. "Development of Tc-99m-DTPA-HSA as a new blood pool scanning agent." Japan.
@misc{etde_6250490,
title = {Development of Tc-99m-DTPA-HSA as a new blood pool scanning agent}
author = {Shirakami, Y, Matsumoto, Y, Yamauchi, Y, Kurami, M, Ueda, N, and Hazue, M}
abstractNote = {A new HSA preparation, Tc-99m-DTPA-HSA, was developed as a blood pool scanning agent. It shows higher labeling yield (more than 95 %) and higher blood retention (74.7 % I.D. at 1 hour post-injection) than Tc-99m-HSA prepared by directly labeling of HSA with Tc-99m. The introduction of DTPA, a strong bifunctional chelating agent, to HSA provides sites for the stable binding of Tc-99m. The preparation composed of 20 mCi of Tc-99m at calibration time and 10 mg of DTPA-HSA in a vial. After labeling, it had been stable for 24 hours at room temperature. In rats, most of Tc-99m-DTPA-HSA injected was metabolized and excreted in urine and feces. The cumulative radioactivity in urine and feces were 56.0 % and 13.7 % of injected dose, respectively, at 48 hours after injection. Metabolites observed in urine were Tc-99m-urea, Tc-99m-DTPA, reduced Tc-99m and so on. Tc-99m-DTPA-HSA proved, thus, a desirable feature for the blood pool scanning agent.}
journal = {Kaku Igaku; (Japan)}
volume = {24:4}
journal type = {AC}
place = {Japan}
year = {1987}
month = {Apr}
}