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RFLP for the human pepsinogen C gene (PGC)

Abstract

PGC 301 is a 1224 bp cDNA clone containing exons 2-9 of the human pepsinogen C (progastericsin) coding sequence. 100 bp deletion/insertion polymorphism is observed with five restriction endonucleases; BamHI, EcoRI, MstII, PstI, and SacI. The same RFLP is observed with these enzymes. The polymorphic region is located between exons 7 and 8. The frequency was estimated from 40 unrelated Caucasians, with the large fragment allele 82.5% and the small fragment allele 17.5%. PGC gene has been assigned to 6p21.1-pter by somatic cell hybrids. Mendelian inheritance was demonstrated in two families.
Publication Date:
Oct 11, 1988
Product Type:
Journal Article
Reference Number:
EDB-89-086856
Resource Relation:
Journal Name: Nucleic Acids Res.; (United Kingdom); Journal Volume: 16:19
Subject:
59 BASIC BIOLOGICAL SCIENCES; GENES; RFLPS; RECOMBINANT DNA; DNA-CLONING; DNA SEQUENCING; HETEROCHROMOSOMES; HUMAN POPULATIONS; PEPSIN; ACID PROTEINASES; CHROMOSOMES; CLONING; DNA; DNA HYBRIDIZATION; ENZYMES; HYBRIDIZATION; HYDROLASES; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PEPTIDE HYDROLASES; POPULATIONS; STRUCTURAL CHEMICAL ANALYSIS; 550200* - Biochemistry
OSTI ID:
6246566
Research Organizations:
Wayne State Univ., Detroit, MI (USA)
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NARHA
Submitting Site:
JMT
Size:
Pages: 9372
Announcement Date:
Feb 11, 1989

Citation Formats

Azuma, T, Pals, G, and Taggart, R T. RFLP for the human pepsinogen C gene (PGC). United Kingdom: N. p., 1988. Web. doi:10.1093/nar/16.19.9372.
Azuma, T, Pals, G, & Taggart, R T. RFLP for the human pepsinogen C gene (PGC). United Kingdom. https://doi.org/10.1093/nar/16.19.9372
Azuma, T, Pals, G, and Taggart, R T. 1988. "RFLP for the human pepsinogen C gene (PGC)." United Kingdom. https://doi.org/10.1093/nar/16.19.9372.
@misc{etde_6246566,
title = {RFLP for the human pepsinogen C gene (PGC)}
author = {Azuma, T, Pals, G, and Taggart, R T}
abstractNote = {PGC 301 is a 1224 bp cDNA clone containing exons 2-9 of the human pepsinogen C (progastericsin) coding sequence. 100 bp deletion/insertion polymorphism is observed with five restriction endonucleases; BamHI, EcoRI, MstII, PstI, and SacI. The same RFLP is observed with these enzymes. The polymorphic region is located between exons 7 and 8. The frequency was estimated from 40 unrelated Caucasians, with the large fragment allele 82.5% and the small fragment allele 17.5%. PGC gene has been assigned to 6p21.1-pter by somatic cell hybrids. Mendelian inheritance was demonstrated in two families.}
doi = {10.1093/nar/16.19.9372}
journal = []
volume = {16:19}
journal type = {AC}
place = {United Kingdom}
year = {1988}
month = {Oct}
}