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Experimental study of the effects of radiation on growing bone by bone scintigraphy

Journal Article:

Abstract

Bones of immature rabbits were irradiated during the growth period, and followed with bone scintigraphy using Tc-99m methylene diphosphonate. The accumulation of the radionuclide was decreased in the irradiated bone at an early period as compared to the control side, and the decrease was more pronounced as the dose of irradiation was increased. In the groups irradiated with less than 4,000 rad, the accumulation ratio reached a minimum at 5 weeks and was followed by a gradual recovery. In the group irradiated with 6,000 rad, the recovery was small; and no recovery was observed in the 8,000 rad group. These changes were compared to the inhibition of the longitudinal growth of the bone. The accumulation ratio for the radionuclide was a more sensitive index of the effect of radiation than the growth rate.
Publication Date:
Feb 01, 1987
Product Type:
Journal Article
Reference Number:
JPN-87-060148; EDB-87-165142
Resource Relation:
Journal Name: Kurume Med. J.; (Japan); Journal Volume: 33:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; TIBIA; BIOLOGICAL RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; LOCAL IRRADIATION; RABBITS; SCINTISCANNING; TECHNETIUM 99; TIME DEPENDENCE; UPTAKE; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; ELECTROMAGNETIC RADIATION; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SKELETON; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6243417
Research Organizations:
Kurume Univ., Fukuoka, Japan. School of Medicine
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: KRMJA
Submitting Site:
JPN
Size:
Pages: 143-148
Announcement Date:

Journal Article:

Citation Formats

Ohtake, Hisashi, Sakai, Yasuhiko, Morita, Seiichiro, Bussaka, Yoshitaka, Kikuchi, Shigeru, Okinaga, Toshichika, Oshibuchi, Masao, and Umezaki, Noriyoshi. Experimental study of the effects of radiation on growing bone by bone scintigraphy. Japan: N. p., 1987. Web.
Ohtake, Hisashi, Sakai, Yasuhiko, Morita, Seiichiro, Bussaka, Yoshitaka, Kikuchi, Shigeru, Okinaga, Toshichika, Oshibuchi, Masao, & Umezaki, Noriyoshi. Experimental study of the effects of radiation on growing bone by bone scintigraphy. Japan.
Ohtake, Hisashi, Sakai, Yasuhiko, Morita, Seiichiro, Bussaka, Yoshitaka, Kikuchi, Shigeru, Okinaga, Toshichika, Oshibuchi, Masao, and Umezaki, Noriyoshi. 1987. "Experimental study of the effects of radiation on growing bone by bone scintigraphy." Japan.
@misc{etde_6243417,
title = {Experimental study of the effects of radiation on growing bone by bone scintigraphy}
author = {Ohtake, Hisashi, Sakai, Yasuhiko, Morita, Seiichiro, Bussaka, Yoshitaka, Kikuchi, Shigeru, Okinaga, Toshichika, Oshibuchi, Masao, and Umezaki, Noriyoshi}
abstractNote = {Bones of immature rabbits were irradiated during the growth period, and followed with bone scintigraphy using Tc-99m methylene diphosphonate. The accumulation of the radionuclide was decreased in the irradiated bone at an early period as compared to the control side, and the decrease was more pronounced as the dose of irradiation was increased. In the groups irradiated with less than 4,000 rad, the accumulation ratio reached a minimum at 5 weeks and was followed by a gradual recovery. In the group irradiated with 6,000 rad, the recovery was small; and no recovery was observed in the 8,000 rad group. These changes were compared to the inhibition of the longitudinal growth of the bone. The accumulation ratio for the radionuclide was a more sensitive index of the effect of radiation than the growth rate.}
journal = {Kurume Med. J.; (Japan)}
volume = {33:3}
journal type = {AC}
place = {Japan}
year = {1987}
month = {Feb}
}