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Effect of low dose x-irradiation on alloantigen sensitized and unsensitized lymphocytes

Journal Article:

Abstract

The effect of local graft irradiation on immune response in allograft in which acute rejection occurs was studied using an in vitro model. Unidirectional mixed lymphocyte culture (MLC) was used as the in vitro model of acute rejection. 150 and 300 rad x-irradiation suppressed mixed lymphocyte reaction (MLR) but did not cell-mediated-lympholysis (CML) of unsensitized lymphocytes. X-irradiated alloantigen sensitized cells (ASC) generated in 6-day MLC suppressed MLR and CML of unsensitized lymphocytes. Suppressive effects of x-irradiated ASC were of the same degree by x-irradiation doses of 150-500 rad. Suppressive effect of x-irradiation was maintained for only a short period after x-irradiation. Potential function of suppressor precursor cells among unsensitized lymphocytes was abolished by x-irradiation of 300 rad. (author).
Publication Date:
Dec 01, 1984
Product Type:
Journal Article
Reference Number:
AIX-17-006244; EDB-86-044866
Resource Relation:
Journal Name: Hiroshima J. Med. Sci.; (Japan); Journal Volume: 33:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; IMMUNOSUPPRESSION; RADIOINDUCTION; LYMPHOCYTES; BIOLOGICAL RADIATION EFFECTS; RETICULOENDOTHELIAL SYSTEM; CELL CULTURES; GRAFTS; IMMUNE REACTIONS; IN VITRO; LOW DOSE IRRADIATION; X RADIATION; ANIMAL CELLS; ANIMAL TISSUES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; IRRADIATION; LEUKOCYTES; MATERIALS; RADIATION EFFECTS; RADIATIONS; SOMATIC CELLS; TISSUES; TRANSPLANTS; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6230570
Research Organizations:
Hiroshima Univ., Japan. School of Medicine
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: HIJMA
Submitting Site:
HEDB
Size:
Pages: 759-763
Announcement Date:
Jan 01, 1986

Journal Article:

Citation Formats

Dohi, Kiyohiko, Yahata, Hiroshi, Fukuda, Yasuhiko, Asahara, Toshimasa, Ono, Eiji, and Ezaki, Haruo. Effect of low dose x-irradiation on alloantigen sensitized and unsensitized lymphocytes. Japan: N. p., 1984. Web.
Dohi, Kiyohiko, Yahata, Hiroshi, Fukuda, Yasuhiko, Asahara, Toshimasa, Ono, Eiji, & Ezaki, Haruo. Effect of low dose x-irradiation on alloantigen sensitized and unsensitized lymphocytes. Japan.
Dohi, Kiyohiko, Yahata, Hiroshi, Fukuda, Yasuhiko, Asahara, Toshimasa, Ono, Eiji, and Ezaki, Haruo. 1984. "Effect of low dose x-irradiation on alloantigen sensitized and unsensitized lymphocytes." Japan.
@misc{etde_6230570,
title = {Effect of low dose x-irradiation on alloantigen sensitized and unsensitized lymphocytes}
author = {Dohi, Kiyohiko, Yahata, Hiroshi, Fukuda, Yasuhiko, Asahara, Toshimasa, Ono, Eiji, and Ezaki, Haruo}
abstractNote = {The effect of local graft irradiation on immune response in allograft in which acute rejection occurs was studied using an in vitro model. Unidirectional mixed lymphocyte culture (MLC) was used as the in vitro model of acute rejection. 150 and 300 rad x-irradiation suppressed mixed lymphocyte reaction (MLR) but did not cell-mediated-lympholysis (CML) of unsensitized lymphocytes. X-irradiated alloantigen sensitized cells (ASC) generated in 6-day MLC suppressed MLR and CML of unsensitized lymphocytes. Suppressive effects of x-irradiated ASC were of the same degree by x-irradiation doses of 150-500 rad. Suppressive effect of x-irradiation was maintained for only a short period after x-irradiation. Potential function of suppressor precursor cells among unsensitized lymphocytes was abolished by x-irradiation of 300 rad. (author).}
journal = {Hiroshima J. Med. Sci.; (Japan)}
volume = {33:4}
journal type = {AC}
place = {Japan}
year = {1984}
month = {Dec}
}