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Deposition, distribution and retention of inhaled /sup 239/PuO/sub 2/ in the lungs of rats with pulmonary emphysema

Journal Article:

Abstract

Individuals with chronic obstructive lung disease, such as emphysema, may be more susceptible to injury from other inhaled pollutants. However, dose-response studies of inhaled radionuclides conducted to aid in estimating the biological effects of inhaled radionuclides in man have typically used healthy laboratory animals. Changes in radionuclide deposition, distribution and retention in the lungs as the result of pre-existing lung diseases could alter the radiation dose or the resulting biological effects. An experimental animal model for human emphysema, in which emphysema is induced by the intratracheal instillation of either elastase or papain, has been reviewed. This model was used to study the effects of pulmonary emphysema on the deposition, distribution and retention of inhaled /sup 239/PuO/sub 2/ in rats.
Authors:
Lundgren, D L; Damon, E G; Diel, J H; Hahn, F F [1] 
  1. Lovelace Foundation for Medical Education and Research, Albuquerque, NM (USA). Inhalation Toxicology Research Inst.
Publication Date:
Feb 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-12-618653; ERA-06-037609; EDB-81-124206
Resource Relation:
Journal Name: Health Phys.; (United Kingdom); Journal Volume: 40:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EMPHYSEMA; RESPONSE MODIFYING FACTORS; PLUTONIUM DIOXIDE; INHALATION; RETENTION; TISSUE DISTRIBUTION; BIOLOGICAL LOCALIZATION; BIOLOGICAL MODELS; LUNGS; PLUTONIUM 239; RADIATION DOSES; RATS; ACTINIDE COMPOUNDS; ACTINIDE ISOTOPES; ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; ANIMALS; BODY; CHALCOGENIDES; DISEASES; DISTRIBUTION; DOSES; EVEN-ODD NUCLEI; HEAVY NUCLEI; INTAKE; ISOTOPES; MAMMALS; NUCLEI; ORGANS; OXIDES; OXYGEN COMPOUNDS; PLUTONIUM COMPOUNDS; PLUTONIUM ISOTOPES; PLUTONIUM OXIDES; RADIOISOTOPES; RESPIRATORY SYSTEM; RESPIRATORY SYSTEM DISEASES; RODENTS; TRANSURANIUM COMPOUNDS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
OSTI ID:
6219860
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: HLTPA
Submitting Site:
INIS
Size:
Pages: 231-235
Announcement Date:

Journal Article:

Citation Formats

Lundgren, D L, Damon, E G, Diel, J H, and Hahn, F F. Deposition, distribution and retention of inhaled /sup 239/PuO/sub 2/ in the lungs of rats with pulmonary emphysema. United Kingdom: N. p., 1981. Web.
Lundgren, D L, Damon, E G, Diel, J H, & Hahn, F F. Deposition, distribution and retention of inhaled /sup 239/PuO/sub 2/ in the lungs of rats with pulmonary emphysema. United Kingdom.
Lundgren, D L, Damon, E G, Diel, J H, and Hahn, F F. 1981. "Deposition, distribution and retention of inhaled /sup 239/PuO/sub 2/ in the lungs of rats with pulmonary emphysema." United Kingdom.
@misc{etde_6219860,
title = {Deposition, distribution and retention of inhaled /sup 239/PuO/sub 2/ in the lungs of rats with pulmonary emphysema}
author = {Lundgren, D L, Damon, E G, Diel, J H, and Hahn, F F}
abstractNote = {Individuals with chronic obstructive lung disease, such as emphysema, may be more susceptible to injury from other inhaled pollutants. However, dose-response studies of inhaled radionuclides conducted to aid in estimating the biological effects of inhaled radionuclides in man have typically used healthy laboratory animals. Changes in radionuclide deposition, distribution and retention in the lungs as the result of pre-existing lung diseases could alter the radiation dose or the resulting biological effects. An experimental animal model for human emphysema, in which emphysema is induced by the intratracheal instillation of either elastase or papain, has been reviewed. This model was used to study the effects of pulmonary emphysema on the deposition, distribution and retention of inhaled /sup 239/PuO/sub 2/ in rats.}
journal = {Health Phys.; (United Kingdom)}
volume = {40:2}
journal type = {AC}
place = {United Kingdom}
year = {1981}
month = {Feb}
}