Abstract
A natural outbreak of ''slobbers'' with high morbidity and high mortality in guinea-pig breeding units in New South Wales and Canberra has been shown to be due to chronic fluoride poisoning. A survey of the dietary regiment employed in laboratories and units demonstrated the association of disease incidence with the feeding of proprietary pellets and usually low levels of green-food supplementation. Fluorine concentration in the pellets used in affected colonies ranged from 130 to 400 ppm. Inquiry produced some evidence that Christmas Island (Indian Ocean) rock-phosphate of high fluoride content had been incorporated in the pellets in place of bone flour. Experimental reproduction of the spontaneous disease was accomplished in exact detail by the extended administration of calcium fluoride in a concentration ranging from 300 to 450 ppm. The fluorine content of skull and teeth samples of experimentally poisoned guinea-pigs was comparable to that in natural cases of slobbers.
Citation Formats
Hard, G C, and Atkinson, F F.V.
Aetiology of ''slobbers'' (chronic fluorosis) in the guinea-pig.
United Kingdom: N. p.,
1967.
Web.
doi:10.1002/path.1700940114.
Hard, G C, & Atkinson, F F.V.
Aetiology of ''slobbers'' (chronic fluorosis) in the guinea-pig.
United Kingdom.
https://doi.org/10.1002/path.1700940114
Hard, G C, and Atkinson, F F.V.
1967.
"Aetiology of ''slobbers'' (chronic fluorosis) in the guinea-pig."
United Kingdom.
https://doi.org/10.1002/path.1700940114.
@misc{etde_6219400,
title = {Aetiology of ''slobbers'' (chronic fluorosis) in the guinea-pig}
author = {Hard, G C, and Atkinson, F F.V.}
abstractNote = {A natural outbreak of ''slobbers'' with high morbidity and high mortality in guinea-pig breeding units in New South Wales and Canberra has been shown to be due to chronic fluoride poisoning. A survey of the dietary regiment employed in laboratories and units demonstrated the association of disease incidence with the feeding of proprietary pellets and usually low levels of green-food supplementation. Fluorine concentration in the pellets used in affected colonies ranged from 130 to 400 ppm. Inquiry produced some evidence that Christmas Island (Indian Ocean) rock-phosphate of high fluoride content had been incorporated in the pellets in place of bone flour. Experimental reproduction of the spontaneous disease was accomplished in exact detail by the extended administration of calcium fluoride in a concentration ranging from 300 to 450 ppm. The fluorine content of skull and teeth samples of experimentally poisoned guinea-pigs was comparable to that in natural cases of slobbers.}
doi = {10.1002/path.1700940114}
journal = []
volume = {94}
journal type = {AC}
place = {United Kingdom}
year = {1967}
month = {Jan}
}
title = {Aetiology of ''slobbers'' (chronic fluorosis) in the guinea-pig}
author = {Hard, G C, and Atkinson, F F.V.}
abstractNote = {A natural outbreak of ''slobbers'' with high morbidity and high mortality in guinea-pig breeding units in New South Wales and Canberra has been shown to be due to chronic fluoride poisoning. A survey of the dietary regiment employed in laboratories and units demonstrated the association of disease incidence with the feeding of proprietary pellets and usually low levels of green-food supplementation. Fluorine concentration in the pellets used in affected colonies ranged from 130 to 400 ppm. Inquiry produced some evidence that Christmas Island (Indian Ocean) rock-phosphate of high fluoride content had been incorporated in the pellets in place of bone flour. Experimental reproduction of the spontaneous disease was accomplished in exact detail by the extended administration of calcium fluoride in a concentration ranging from 300 to 450 ppm. The fluorine content of skull and teeth samples of experimentally poisoned guinea-pigs was comparable to that in natural cases of slobbers.}
doi = {10.1002/path.1700940114}
journal = []
volume = {94}
journal type = {AC}
place = {United Kingdom}
year = {1967}
month = {Jan}
}