Abstract
A noninvasive useful method is required to early ascertain the effect of intracoronary thrombolysis (ICT) currently performed for acute myocardial infarction (AMI). In the present study, Tc-99m-pyrophosphate (PYP) scintigraphy was performed early (2.8 - 9.3 hr) after the onset of symptoms in 34 patients undergoing ICT. Of 27 patients in whom favorable recanalization was obtained, 24 had positive early scintigrams. In the other 7 patients in whom ICT was unsuccessful, scintigrams were negative. In 3 of them, favorable collateral circulation was seen. The findings were compared with those within 16 hr after the onset for the peak levels of creatine kinase (CK) and MB-CK. Early PYP scintigraphy had a sensitivity of 89 %, specificity of 100 %, and predictive accuracy of 91 % in assessing the recanalization in the infarcted vessels. The corresponding figiures were 70 %, 86 %, and 74 % for CK levels; and 70 %, 71 %, and 71 % for MB-CK levels. The results indicate that PYP scintigraphy may be a useful aid in the diagnosis of recanalization. The mechanism for PYP uptake on early scintigrams may be explained by the passage of excessive Ca ion into the ischemic myocardial cells through the rapid recanalization, resulting
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Citation Formats
Kondo, Makoto, Yuzuki, Yousuke, Miyazaki, Yukio, Kurose, Takesi, Matsunaga, Kazuhiko, and Simono, Yukio.
Clinical assessment of the early myocardial Tc-99m-PYP uptake as an indicator of successful recanalization in the acutely infarcted vessels.
Japan: N. p.,
1986.
Web.
Kondo, Makoto, Yuzuki, Yousuke, Miyazaki, Yukio, Kurose, Takesi, Matsunaga, Kazuhiko, & Simono, Yukio.
Clinical assessment of the early myocardial Tc-99m-PYP uptake as an indicator of successful recanalization in the acutely infarcted vessels.
Japan.
Kondo, Makoto, Yuzuki, Yousuke, Miyazaki, Yukio, Kurose, Takesi, Matsunaga, Kazuhiko, and Simono, Yukio.
1986.
"Clinical assessment of the early myocardial Tc-99m-PYP uptake as an indicator of successful recanalization in the acutely infarcted vessels."
Japan.
@misc{etde_6215175,
title = {Clinical assessment of the early myocardial Tc-99m-PYP uptake as an indicator of successful recanalization in the acutely infarcted vessels}
author = {Kondo, Makoto, Yuzuki, Yousuke, Miyazaki, Yukio, Kurose, Takesi, Matsunaga, Kazuhiko, and Simono, Yukio}
abstractNote = {A noninvasive useful method is required to early ascertain the effect of intracoronary thrombolysis (ICT) currently performed for acute myocardial infarction (AMI). In the present study, Tc-99m-pyrophosphate (PYP) scintigraphy was performed early (2.8 - 9.3 hr) after the onset of symptoms in 34 patients undergoing ICT. Of 27 patients in whom favorable recanalization was obtained, 24 had positive early scintigrams. In the other 7 patients in whom ICT was unsuccessful, scintigrams were negative. In 3 of them, favorable collateral circulation was seen. The findings were compared with those within 16 hr after the onset for the peak levels of creatine kinase (CK) and MB-CK. Early PYP scintigraphy had a sensitivity of 89 %, specificity of 100 %, and predictive accuracy of 91 % in assessing the recanalization in the infarcted vessels. The corresponding figiures were 70 %, 86 %, and 74 % for CK levels; and 70 %, 71 %, and 71 % for MB-CK levels. The results indicate that PYP scintigraphy may be a useful aid in the diagnosis of recanalization. The mechanism for PYP uptake on early scintigrams may be explained by the passage of excessive Ca ion into the ischemic myocardial cells through the rapid recanalization, resulting in accelerated cell death (reperfusion necrosis). (Namekawa, K.).}
journal = []
volume = {18:11}
journal type = {AC}
place = {Japan}
year = {1986}
month = {Nov}
}
title = {Clinical assessment of the early myocardial Tc-99m-PYP uptake as an indicator of successful recanalization in the acutely infarcted vessels}
author = {Kondo, Makoto, Yuzuki, Yousuke, Miyazaki, Yukio, Kurose, Takesi, Matsunaga, Kazuhiko, and Simono, Yukio}
abstractNote = {A noninvasive useful method is required to early ascertain the effect of intracoronary thrombolysis (ICT) currently performed for acute myocardial infarction (AMI). In the present study, Tc-99m-pyrophosphate (PYP) scintigraphy was performed early (2.8 - 9.3 hr) after the onset of symptoms in 34 patients undergoing ICT. Of 27 patients in whom favorable recanalization was obtained, 24 had positive early scintigrams. In the other 7 patients in whom ICT was unsuccessful, scintigrams were negative. In 3 of them, favorable collateral circulation was seen. The findings were compared with those within 16 hr after the onset for the peak levels of creatine kinase (CK) and MB-CK. Early PYP scintigraphy had a sensitivity of 89 %, specificity of 100 %, and predictive accuracy of 91 % in assessing the recanalization in the infarcted vessels. The corresponding figiures were 70 %, 86 %, and 74 % for CK levels; and 70 %, 71 %, and 71 % for MB-CK levels. The results indicate that PYP scintigraphy may be a useful aid in the diagnosis of recanalization. The mechanism for PYP uptake on early scintigrams may be explained by the passage of excessive Ca ion into the ischemic myocardial cells through the rapid recanalization, resulting in accelerated cell death (reperfusion necrosis). (Namekawa, K.).}
journal = []
volume = {18:11}
journal type = {AC}
place = {Japan}
year = {1986}
month = {Nov}
}