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Characterization of DNA polymerase. beta. mRNA: cell-cycle growth response in cultured human cells

Journal Article:

Abstract

DNA polymerase ..beta.. (..beta..-polymerase) is a housekeeping enzyme involved in DNA repair in vertebrate cells. The authors used a cDNA probe to study abundance of ..beta..-polymerase mRNA in cultured human cells. The mRNA level in synchronized HeLa cells, representing different stages of the cell-cycle, varied only slightly. Contact inhibited fibroblasts AG-1522 contained the same level of mRNA as growing cells. The steady-state level of mRNA in fibroblasts is equivalent to 6 molecules per cell. The results indicate that the ..beta..-polymerase transcript is low abundance and is neither cell-cycles nor growth phase responsive.
Publication Date:
Oct 25, 1988
Product Type:
Journal Article
Reference Number:
EDB-89-086848
Resource Relation:
Journal Name: Nucleic Acids Res.; (United Kingdom); Journal Volume: 16:20
Subject:
59 BASIC BIOLOGICAL SCIENCES; DNA POLYMERASES; BIOCHEMISTRY; HELA CELLS; DNA REPAIR; MESSENGER-RNA; HYBRIDIZATION; CELL CULTURES; CELL CYCLE; FIBROBLASTS; RECOMBINANT DNA; ANIMAL CELLS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; CHEMISTRY; CONNECTIVE TISSUE CELLS; DNA; ENZYMES; NUCLEIC ACIDS; NUCLEOTIDYLTRANSFERASES; ORGANIC COMPOUNDS; PHOSPHORUS-GROUP TRANSFERASES; POLYMERASES; RECOVERY; REPAIR; RNA; SOMATIC CELLS; TRANSFERASES; 550200* - Biochemistry
OSTI ID:
6210432
Research Organizations:
National Institutes of Health, Bethesda, MD (USA)
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NARHA
Submitting Site:
JMT
Size:
Pages: 9587-9596
Announcement Date:

Journal Article:

Citation Formats

Zmudzka, B Z, Fornace, A, Collins, J, and Wilson, S H. Characterization of DNA polymerase. beta. mRNA: cell-cycle growth response in cultured human cells. United Kingdom: N. p., 1988. Web. doi:10.1093/nar/16.20.9587.
Zmudzka, B Z, Fornace, A, Collins, J, & Wilson, S H. Characterization of DNA polymerase. beta. mRNA: cell-cycle growth response in cultured human cells. United Kingdom. doi:10.1093/nar/16.20.9587.
Zmudzka, B Z, Fornace, A, Collins, J, and Wilson, S H. 1988. "Characterization of DNA polymerase. beta. mRNA: cell-cycle growth response in cultured human cells." United Kingdom. doi:10.1093/nar/16.20.9587. https://www.osti.gov/servlets/purl/10.1093/nar/16.20.9587.
@misc{etde_6210432,
title = {Characterization of DNA polymerase. beta. mRNA: cell-cycle growth response in cultured human cells}
author = {Zmudzka, B Z, Fornace, A, Collins, J, and Wilson, S H}
abstractNote = {DNA polymerase ..beta.. (..beta..-polymerase) is a housekeeping enzyme involved in DNA repair in vertebrate cells. The authors used a cDNA probe to study abundance of ..beta..-polymerase mRNA in cultured human cells. The mRNA level in synchronized HeLa cells, representing different stages of the cell-cycle, varied only slightly. Contact inhibited fibroblasts AG-1522 contained the same level of mRNA as growing cells. The steady-state level of mRNA in fibroblasts is equivalent to 6 molecules per cell. The results indicate that the ..beta..-polymerase transcript is low abundance and is neither cell-cycles nor growth phase responsive.}
doi = {10.1093/nar/16.20.9587}
journal = {Nucleic Acids Res.; (United Kingdom)}
volume = {16:20}
journal type = {AC}
place = {United Kingdom}
year = {1988}
month = {Oct}
}